A New Flavone from Flos Sophorae Immaturus Through Microbial Transformation by Nigrospora sphaerica ZMT05

  • Jiaqing Chen
  • Xiaoling Zhang
  • Weilin Li
  • Tong Li
  • Weijia DingEmail author
  • Chunyuan LiEmail author

A new flavone derivative, 3′-(γ,γ-dimethylallyloxy)-5,7-dihydroxy-4′-methoxyflavone (1), was isolated from Flos Sophorae Immaturus through microbial transformation by the fungus Nigrospora sphaerica ZMT05. Its structure was elucidated by comprehensive spectroscopic analyses. This compound showed moderate in vitro antifungal activities against Colletotrichum musae and Penicillium italicum.


flavone antifungal activity microbial transformation Nigrospora sp 



This work was supported by the National Natural Science Foundation of China (21102049), the Natural Science Foundation of Guangdong Province (2018A030313582, 2015A030313405), the Science and Technology Project for Public Welfare Research and Capacity Building of Guangdong Province (2016A020222019), the Science and Technology Project of Guangzhou City (201707010342), the Scientific Research Foundation for Returning Overseas Chinese Scholars, State Education Ministry (Grant Number [2015] 311), and the Innovation Experiment Program for University Students of South China Agricultural University (201810564494, 201810564499).


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Authors and Affiliations

  1. 1.College of Materials and EnergySouth China Agricultural UniversityGuangzhouP. R. China

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