Chemistry of Natural Compounds

, Volume 55, Issue 5, pp 890–894 | Cite as

A New Triterpene and a New Phloroglucinol Derivative from the Aerial Parts of Pogostemon auricularius

  • Duc Viet Ho
  • Linh Thuy Thi Tran
  • Dung Viet Le
  • Hung Manh Tran
  • Nhan Trong Le
  • Anh Tuan Le
  • Hoai Thi NguyenEmail author
  • Ain RaalEmail author

A new triterpene, pogostem (1), and a new phloroglucinol derivative, pogostemon D (2), were isolated from the aerial parts of Pogostemon auricularius (L.) Hassk. Their structures were determined from a combination of 1D NMR, 2D NMR, and HR-ESI-MS. Furthermore, pogostem (1) inhibited the proliferation of five human cancer cell lines, KB, SW-480, AGS, Hep-G2, and LU-1, with IC50 values ranging from 45.92 ± 5.65 to 65.83 ± 7.05 μg/mL.


Pogostemon auricularius Lamiaceae pogostemon pogostem cytotoxicity 



The authors received no direct funding for this research. We are grateful to Mr. Anh Tuan Le (Mientrung Inst. for Scientific Research, VAST, Quang Tri, Vietnam) for collecting the plant material and Mr. Luong Vu Dang (Institute of Chemistry, VAST, Hanoi, Vietnam). We thank Renee Mosi, PhD, from Edanz Group ( for editing a draft of this manuscript.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Duc Viet Ho
    • 1
  • Linh Thuy Thi Tran
    • 1
    • 2
  • Dung Viet Le
    • 2
  • Hung Manh Tran
    • 3
  • Nhan Trong Le
    • 1
  • Anh Tuan Le
    • 4
  • Hoai Thi Nguyen
    • 1
    Email author
  • Ain Raal
    • 5
    Email author
  1. 1.Faculty of Pharmacy, Hue University of Medicine and PharmacyHue UniversityHue CityVietnam
  2. 2.National Institute of Medicinal MaterialsHanoi CityVietnam
  3. 3.Medicinal Chemistry Division, Faculty of Chemistry, University of ScienceVietnam National UniversityHochiminh CityVietnam
  4. 4.Quang Tri Center of Science and Technology, Mientrung Inst. for Scientific Research, VASTQuang TriVietnam
  5. 5.Institute of Pharmacy, Faculty of MedicineUniversity of TartuTartuEstonia

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