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Search for Antimicrobial Compounds Among Maleopimaric-Acid Derivatives

  • G. F. VafinaEmail author
  • M. D. Khanova
  • S. A. Meshcheryakova
  • A. K. Bulgakov
Article
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The antimicrobial and antifungal activities of maleopimaric acid (MPA) and several of its 2- and 6-derivatives were investigated. An analysis of the results showed pronounced antimicrobial activity for 2-allylmaleopimarimide and MPA N-benzylcarboxamide against test strains of Gram-negative and Gram-positive microorganisms and antifungal activity of 2-allylmaleopimarimide against lower-fungus test strain Candida albicans. New methods for producing MPA N-benzylcarboxamide and N-hydroxymaleopimarimide that increased the yields of target products were proposed.

Keywords

maleopimaric acid antimicrobial activity antifungal activity 

Notes

Acknowledgment

The work was sponsored by RAS Presidium Program No. 38 “Basic research on synthetic problems and structure–activity relationships to design new compounds and materials.”

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • G. F. Vafina
    • 1
    Email author
  • M. D. Khanova
    • 1
  • S. A. Meshcheryakova
    • 2
  • A. K. Bulgakov
    • 2
  1. 1.Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of SciencesUfaRussia
  2. 2.Bashkir State Medical University, Ministry of Health of the Russian FederationUfaRussia

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