Two New Isobenzofuranone Derivatives from Phyllanthus emblica and Their Bioactivity
Two new isobenzofuranone derivatives, 5-(2-hydroxyethyl)-2,2-dimethyl-2H-furo[3,4-h]chromen-7(9H)-one (1) and 2,2-dimethyl-5-(2-oxopropyl)-2H-furo[3,4-h]chromen-7(9H)-one (2), were isolated from the fruit of Phyllanthus emblica. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were also tested for their antioxidant activity, and they show good antioxidant activity with an IC50 value of 4.5 and 4.2 μg/mL, respectively.
Keywordsisobenzofuranone derivatives Phyllanthus emblica antioxidant activity
This research was supported by the Research Foundation of China Tobacco Yunnan Industrial Co., Ltd (No. 2017JC05), the National Natural Science Foundation of China (Nos. 81660717 and 21462051), and the Natural Science Foundation of Yunnan Province (No. 2014FD033).
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