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Two New Isobenzofuranone Derivatives from Phyllanthus emblica and Their Bioactivity

  • Qian Gao
  • Hai-Ying Xiang
  • Wei Chen
  • Jun Ling
  • Xing Chen
  • Jing Li
  • Tian-dong Zhang
  • Xue-Mei Li
  • Min Zou
  • Guang-Yu YangEmail author
  • Qiu-Fen HuEmail author
Article

Two new isobenzofuranone derivatives, 5-(2-hydroxyethyl)-2,2-dimethyl-2H-furo[3,4-h]chromen-7(9H)-one (1) and 2,2-dimethyl-5-(2-oxopropyl)-2H-furo[3,4-h]chromen-7(9H)-one (2), were isolated from the fruit of Phyllanthus emblica. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were also tested for their antioxidant activity, and they show good antioxidant activity with an IC50 value of 4.5 and 4.2 μg/mL, respectively.

Keywords

isobenzofuranone derivatives Phyllanthus emblica antioxidant activity 

Notes

Acknowledgment

This research was supported by the Research Foundation of China Tobacco Yunnan Industrial Co., Ltd (No. 2017JC05), the National Natural Science Foundation of China (Nos. 81660717 and 21462051), and the Natural Science Foundation of Yunnan Province (No. 2014FD033).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Qian Gao
    • 1
    • 2
  • Hai-Ying Xiang
    • 1
  • Wei Chen
    • 1
  • Jun Ling
    • 1
  • Xing Chen
    • 1
  • Jing Li
    • 1
  • Tian-dong Zhang
    • 2
  • Xue-Mei Li
    • 2
  • Min Zou
    • 2
  • Guang-Yu Yang
    • 1
    Email author
  • Qiu-Fen Hu
    • 2
    Email author
  1. 1.China Tobacco Yunnan Industrial Co., LtdKunmingP. R. China
  2. 2.Key Laboratory of Chemistry in Ethnic Medicinal ResourcesYunnan Minzu UniversityKunmingP. R. China

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