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Two New Diphenyl Ether Derivatives from the Fermentation Products of the Endophytic Fungus Phomopsis asparagi

  • Shan-Shan Hu
  • Meng-Jie Liang
  • Qi-Li Mi
  • Wei Chen
  • Jun Ling
  • Xing Chen
  • Jing Li
  • Guang-Yu Yang
  • Qiu-Fen Hu
  • Wei-Guang WangEmail author
  • Ya-Dong GuoEmail author
Article
  • 5 Downloads

Two new diphenyl ethers (1 and 2) were isolated from the fermentation products of an endophytic fungus Phomopsis asparagi. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compounds 1 and 2 showed good inhibition with IZD 10.8 ± 2.0 and 11.4 ± 1.8 mm, respectively.

Keywords

diphenyl ethers endophytic fungus Phomopsis asparagi anti-MRSA activity 

Notes

Acknowledgment

This research was supported by the National Natural Science Foundation of China (Nos. 21462051, 21562049, 31360081, and 31400303), and the Research Foundation of China Tobacco Company (No. 110201502006), and the Research Foundation of China Tobacco Yunnan Industrial Co., Ltd. (Nos. 2015539200340277 and 2016JC03).

References

  1. 1.
    I. T. Malik and H. Brotz-Oesterhelt, Nat. Prod. Rep., 34, 815 (2017).CrossRefGoogle Scholar
  2. 2.
    C. Schinke, T. Martins, S. C. N. Queiroz, I. S. Melo, and F. G. R. Reyes, J. Nat. Prod., 80, 1215 (2017).CrossRefGoogle Scholar
  3. 3.
    M. Z. Zhang, Y. Qiao, E. L. Ang, and H. M. Zhao, Expert Opin. Drug Discov., 12, 475 (2017).CrossRefGoogle Scholar
  4. 4.
    H. Choi and D. C. Oh, Arch. Pharm. Res., 38, 1591 (2015).CrossRefGoogle Scholar
  5. 5.
    J. W. Blunt, B. R. Copp, R. A. Keyzers, M. H. G. Munro, and M. R. Prinsep, Nat. Prod. Rep., 34, 235 (2017).CrossRefGoogle Scholar
  6. 6.
    H. B. Liu, K. Lohith, M. Rosario, T. H. Pulliam, R. D. O′Connor, L. J. Bell, and C. A. Bewley, J. Nat. Prod., 79, 1872 (2016).CrossRefGoogle Scholar
  7. 7.
    Z. J. Li, H. Y. Yang, J. Li, X. Liu, L. Ye, W. S. Kong, S. Y. Tang, G. Du, Z. H. Liu, M. Zhou, G. Y. Yang, Q. F. Hu, and X. M. Li, J. Antibiot., 71, 359 (2018).CrossRefGoogle Scholar
  8. 8.
    P. L. N. de Carvalho, E. D. Silva, D. A. Chagas-Paula, J. H. H. Luiz, and M. Ikegaki, Mini-Rev. Med. Chem., 16, 259 (2016).CrossRefGoogle Scholar
  9. 9.
    S. K. Deshmukh, S. A. Verekar, and S. Bhave, Front. Microbiol., 5, DOI:  https://doi.org/10.3389/fmicb.2014.00715 (2015).
  10. 10.
    S. Kaul, S. Gupta, M. Ahmed, and M. K. Dhar, Phytochem. Rev., 11, 487 (2012).CrossRefGoogle Scholar
  11. 11.
    Q. F. Hu, Y. C. Yang, S. Yang, H. Y. Cao, C. Y. Meng, H. Y. Yang, X. M. Gao, and G. Du, Chem. Nat. Compd., 51, 456 (2015).CrossRefGoogle Scholar
  12. 12.
    L. Yuan, W. Z. Huang, G. Du, X. M. Gao, H. Y. Yang, Q. F. Hu, and Y. H. Ma, Chem. Nat. Compd., 51, 460 (2015).CrossRefGoogle Scholar
  13. 13.
    Y. Meng, Y. Yang, Y. Qin, C. Xia, M. Zhou, X. Gao, G. Du, and Q. F. Hu, Nat. Prod. Commun., 10, 305 (2015).Google Scholar
  14. 14.
    H. Y. Yang, Y. H. Gao, D. Y. Niu, L. Y. Yang, X. M. Gao, G. Du, and Q. F. Hu, Fitoterapia, 91, 189 (2013).CrossRefGoogle Scholar
  15. 15.
    G. Du, Z. C. Wang, W. Y. Hu, K. L. Yan, X. L. Wang, H. M. Yang, H. Y. Yang, Y. H. Gao, Q. Liu, and Q. F. Hu, Phytochem. Lett., 21, 287 (2017).CrossRefGoogle Scholar
  16. 16.
    H. Y. Yang, Y. Q. Duan, Y. K. Yang, J. Li, X. Liu, L. Ye, Q. L. Mi, W. S. Kong, M. Zhou, G. Y. Yang, X. M. Li, and Q. F. Hu, Phytochem. Lett., 22, 266 (2017).CrossRefGoogle Scholar
  17. 17.
    Reference Method for Broth Dilution, Antifungal Susceptibility Testing of Yeasts; Approved Standarts, Clinical and Laboratory Standards Institute (CLSI), Third ed., Wayne, Pennsylvania, 2008.Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Shan-Shan Hu
    • 1
  • Meng-Jie Liang
    • 1
  • Qi-Li Mi
    • 2
  • Wei Chen
    • 2
  • Jun Ling
    • 2
  • Xing Chen
    • 2
  • Jing Li
    • 2
  • Guang-Yu Yang
    • 1
    • 3
  • Qiu-Fen Hu
    • 2
    • 3
  • Wei-Guang Wang
    • 2
    • 3
    Email author
  • Ya-Dong Guo
    • 1
    Email author
  1. 1.School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural ProductsKunming Medical UniversityKunmingP. R. China
  2. 2.Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., LtdKunmingP. R. China
  3. 3.Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of EducationYunnan Minzu UniversityKunmingP. R. China

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