Two New Diphenyl Ether Derivatives from the Fermentation Products of the Endophytic Fungus Phomopsis asparagi
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Two new diphenyl ethers (1 and 2) were isolated from the fermentation products of an endophytic fungus Phomopsis asparagi. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compounds 1 and 2 showed good inhibition with IZD 10.8 ± 2.0 and 11.4 ± 1.8 mm, respectively.
Keywordsdiphenyl ethers endophytic fungus Phomopsis asparagi anti-MRSA activity
This research was supported by the National Natural Science Foundation of China (Nos. 21462051, 21562049, 31360081, and 31400303), and the Research Foundation of China Tobacco Company (No. 110201502006), and the Research Foundation of China Tobacco Yunnan Industrial Co., Ltd. (Nos. 2015539200340277 and 2016JC03).
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