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Phenolic Acids from the Seeds of Sophora alopecuroides

  • Ping Song
  • Hao Chen
  • Yun Huang
  • Yanzhang Wen
  • Ji Hao
  • Yibing Lv
  • Shihao DengEmail author
  • Xinzhou YangEmail author
Article
  • 7 Downloads

Chemical profiling of the EtOAc extract from a traditional Chinese medicine Sophora alopecuroides yielded a new phenolic acid, (3S,2R)-methyl 2-(4-hydroxybenzyl)tartrate (1), along with four known compounds, eucomic acid (2), methyl eucomate (3), piscidic acid (4), and ethyl 2-(4-hydroxybenzyl)tartrate (5). The structure of 1 was determined by extensive spectral analyses including 1D and 2D NMR and MS data. All compounds were evaluated for their cytotoxic activities against HepG2 and Hep3B hepatocellular carcinoma (HCC) cell lines. Compounds 1–5 showed weak anti-HCC activities.

Keywords

Sophora alopecuroides phenolic acid cytotoxity 

Notes

Acknowledgment

This work was financially supported by the grant of Natural Science Foundation of Qinghai Province (No. 2016-ZJ-908) and Wuhan Applied Basic Research Program of Science and Technology (2017060201010217).

References

  1. 1.
    H. T. Bian, J. Zhao, and H. Huang, J. Chin. Med. Mater., 37, 72 (2014).Google Scholar
  2. 2.
    C. Guo, L. Yang, and C. X. Wan, Phytomedicine, 23, 1629 (2016).CrossRefGoogle Scholar
  3. 3.
    M. Iinuma, J. Yokoyama, and M. Ohyama, Phytochemistry, 33, 203 (1999).CrossRefGoogle Scholar
  4. 4.
    X. Zhou, F. Jia, and X. Liu, Chin. J. Integr. Med., 19, 945 (2013).CrossRefGoogle Scholar
  5. 5.
    A. Mun’im, O. Negishi, and T. Ozawa, Biosci. Biotechnol. Biochem., 67, 410 (2003).Google Scholar
  6. 6.
    J. Z. Song, H. X. Xu, and S. J. Tian, J. Chromatogr. A., 857, 303 (1999).CrossRefGoogle Scholar
  7. 7.
    J. Jiang, Y. Li, and Z. Chen, Steroids, 71, 1073 (2006).CrossRefGoogle Scholar
  8. 8.
    H. Toshima, M. Saito, and T. Yoshihara, Biosci. Biotechnol. Biochem., 63, 964 (1999).CrossRefGoogle Scholar
  9. 9.
    C. Luo, W. Zhang, and C. Sheng, Chem. Biodiv., 7, 2869 (2010).CrossRefGoogle Scholar
  10. 10.
    J. Yang, C. Xu, H. Chen, M. Huang, X. H. Ma, S. H. Deng, Y. Huang, Y. Z. Wen, X. Z. Yang, and P. Song, Biomed. Pharmacother., 96, 1199 (2017).CrossRefGoogle Scholar
  11. 11.
    E. M. Suleimen, G. G. Sisengalieva, R. I. Dzhalmakhanbetova, Zh. B. Iskakova, and M. Yu. Ishmuratova, Chem. Nat. Compd., 54, 1177 (2018).CrossRefGoogle Scholar
  12. 12.
    S. A. Pukhov, S. V. Afanas'eva, L. V. Anikina, V. I. Kozlovskii, M. E. Neganova, and S. G. Klochkov, Chem. Nat. Compd., 55, 41 (2019).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Science & TechnologyQinghai University for NationalitiesXilingP. R. China
  2. 2.School of Pharmaceutical SciencesSouth-Central University for NationalitiesWuhanP. R. China

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