Acetylated Nucleoside Derivatives from a Shallow-Water Marine Bivalve Codakia orbicularis
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Codakia orbicularis (Linnaeus, 1758) individuals (40–60 mm shell length) were collected from August to December 2015 by hand from Thalassia testudinum sea-grass sediments in Guadeloupe (lat 16°09′01.7′′N, long 61°33′42.9′′W). These bivalves were identified by Prof. Olivier Gros (bivalve specialist). Fresh gills from 2000 individuals were dissected, pooled, and frozen at –20°C before chemical extraction. The first study on the marine mollusk Codakia orbicularis used all soft tissues of this bivalve and led mostly to phospholipids, triglycerides, fatty acids, and sterols . Some 20 years later, a second chemical study focusing on gill tissues of this bivalve led to the discovery of a new lectine, called codakine . From the gills of this lucinid, we have recently isolated a new spiro-indolothiazine, named orbicularisine .
Three kilograms of gills were extracted by agitation in 200 mL of ethyl acetate (EtOAc) during 12 h at room temperature. The heterogeneous mixture was filtered...
This work was supported by the Region Guadeloupe.
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