Secondary Metabolites of Two Lichen-Derived Streptomyces
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Lichens are symbiotic associations between fungi and photobionts, which can be algae or cyanobacteria. They are slow growing, stress-tolerant organisms, which provide a habitat for a variety of bacteria, including actinomycetes . Recent studies have shown that most of the lichen-associated actinomycetes have broad spectrum antibacterial activity, of which Streptomyces are most prominent . However, up to now, there are only a few bioactive substances reported from lichen-associated actinomyces, including antibaterial BE-24566B  and uncialamycin , cytotoxic cladoniamides  and angucycline , and antiproliferative cyaneodimycin . Our current study is aimed to investigate the bioactive secondary metabolites from lichen-associated actinomycetes.
Two Streptomyces strains YIM 130597 and YIM 130932 isolated from the lichen Punctelia rudectain Yunnan Province, P. R. China, were found to exhibit obvious antibacterial activity. We have studied the secondary metabolites of...
This work was supported by grants from the National Natural Science Foundation of China (Program Nos. 81860634 and 81460545) and the Program for Excellent Young Talents, Yunnan University.
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