Serratanes from Whole Plant of Palhinhaea cernua
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The club moss Palhinhaea cernua (Lycopodium cernuum) of the family Lycopodiaceae is a perennial herb mainly distributed in Eastern and Southern China, the dried whole plant of which is historically used as a traditional Chinese medicine (TCM) for the treatment of rheumatism, whooping cough, contusions, scalds, hepatitis, and nephrolithiasis [1, 2]. Previously, an array of structurally interesting secondary metabolites, mainly serratane-type triterpenoids and Lycopodium alkaloids, were isolated from this plant [3, 4]. These isolated constituents have attracted a great deal of interest due of their wide range of biological activities, such as the inhibitory activities against cholinesterases and β-secretase 1, which were regarded as the key targets for the treatment of Alzheimer′s disease (AD) [3, 5]. As part of our research on structurally unique and biologically active metabolites from the Chinese medicinal plants , we investigated the title plant.
The dried and powdered whole plant...
This study was supported by the National Natural Science Foundation of China (41876194 and 41506187), the Hunan Provincial Natural Science Foundation of China (2015JJ3176), a Project Supported by Scientific Research Fund of Hunan Provincial Education Department (16C1674), and grants from Foshan University.
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