Chemistry of Natural Compounds

, Volume 55, Issue 4, pp 716–718 | Cite as

Neoflavonoid Angelicin Derivatives

  • T. V. ShokolEmail author
  • V. S. Moskvina
  • E. K. Glebov
  • V. P. Khilya

Furocoumarins form one of the most important classes of natural flavonoids with photosensitizing action that are used therapeutically for psoriasis, fungal mycosis, and cancer [1, 2]. The simplest angular furocoumarin angelicin (isopsoralen) occurs in plants of the family Apiaceae [3] and exhibits antioxidant, anti-inflammatory, membrane-stabilizing, and anabolic activity [4]. 4-Alkyl-8-aroyl-9-arylangelicin derivatives exhibited antiviral activity against influenza A (H1N1) [5] and were patented as agents for cancer treatment [6]. Natural neoflavanoid angelicin derivatives and their analogs with hydrogenated furan rings were isolated from bark of Ochrocarpos punctatus and Mammea neurophylla [7, 8, 9]. Furanoracemosone was isolated from leaves of Mesua racemosa [10]; its analogs, from bark and fruit of Calophyllum dispar [11].

Two approaches were previously used to synthesize 4-phenylfuro[2,3-h]coumarins, i.e., annelation of an α-pyrone ring to benzofuran via intramolecular...


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • T. V. Shokol
    • 1
    Email author
  • V. S. Moskvina
    • 1
  • E. K. Glebov
    • 1
  • V. P. Khilya
    • 1
  1. 1.Taras Shevchenko National University of KyivKievUkraine

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