Chemistry of Natural Compounds

, Volume 55, Issue 4, pp 689–691 | Cite as

New Clerodane Diterpenoid from Pulicaria gnaphalodes

  • B. D. Komilov
  • K. A. EshbakovaEmail author
  • H. A. Aisa

The new clerodane-type diterpenoid gnapholone (1) was isolated from the aerial part of Pulicaria gnaphalodes. Spectral data established the structure of 1 as 7-oxo-15,16-epoxy-trans-cleroda-3,13(14)-dien-19,6-olide.


Pulicaria gnaphalodes (Asteraceae) clerodane-type diterpenoid PMR 13C NMR HSQC and HMBC spectra 



The work was financially supported by the Applied Scientific Research Program of the AS, RUz (Grant P3-20170927122); International Science and Technology Center Projects (Grant No. 2016YFE0120600), and the Central Asian Center of Drug Discovery and Development, Chinese Academy of Sciences.


  1. 1.
    K. A. Eshbakova, Kh. I. Khasanova, B. D. Komilov, Sh. O. Melieva, and H. A. Aisa, Chem. Nat. Compd., 54, 360 (2018).CrossRefGoogle Scholar
  2. 2.
    K. A. Eshbakova, Z. O. Toshmatov, Sh. O. Melieva, H. A. Aisa, and N. D. Abdullaev, Chem. Nat. Compd., 52, 713 (2016).CrossRefGoogle Scholar
  3. 3.
    K. A. Eshbakova, A. Yili, and H. A. Aisa, Chem. Nat. Compd., 50, 737 (2014).CrossRefGoogle Scholar
  4. 4.
    K. A. Eshbakova, Medicinal Plants, 3 (2), 161 (2011).Google Scholar
  5. 5.
    K. A. Eshbakova and A. I. Saidkhodzhaev, Chem. Nat. Compd., 37, 197 (2001).CrossRefGoogle Scholar
  6. 6.
    Biswanath Das, M. Ravinder Reddy, R. Ramu, N. Ravindranath, H. Harish, K. V. S. Ramakrishna, Y. Koteswar Rao, K. Harakishore, and U. S. N. Murthy, Phytochemistry, 66, 633 (2005).CrossRefGoogle Scholar
  7. 7.
    M. R. Nurmukhamedova, Sh. Z. Kasymov, N. D. Abdullaev, G. P. Sidyakin, and M. R. Yagudaev, Chem. Nat. Compd., 21, 188 (1985).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • B. D. Komilov
    • 1
  • K. A. Eshbakova
    • 1
    • 2
    Email author
  • H. A. Aisa
    • 2
    • 3
  1. 1.S. Yu. Yunusov Institute of the Chemistry of Plant SubstancesAcademy of Sciences of the Republic of UzbekistanTashkentUzbekistan
  2. 2.Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and ChemistryChinese Academy of SciencesUrumqiP. R. China
  3. 3.Key Laboratory of Xinjiang Indigenous Medicinal Plant Resources Utilization, Xinjiang Technical Institute of Physics and ChemistryChinese Academy of SciencesUrumqiP. R. China

Personalised recommendations