A New Totarane Diterpenoid from the Rhizomes of Isodon lophanthoides
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A new totarane diterpenoid, 7β,15-dihydroxytotarol-19-oic acid (1), along with six known diterpenoids (2–7) and seven known triterpenoids (8–14), were isolated from the EtOAc-soluble fraction of the 70% acetone extract of rhizomes of Isodon lophanthoides. Their structures were elucidated based on the analysis of extensive spectroscopic data. The antimalarial activities of all the isolated diterpenoids were measured by the β-hematin formation inhibition assay in vitro. Compounds 2 and 4 showed moderate activities.
KeywordsIsodon lophanthoides Labiatae chemical constituents totarane diterpenoids β-hematin formation inhibition activity
This work was financially supported by the National Natural Science Foundation of China (Grant Nos. 81460532 and 81641187).
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