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Chemistry of Natural Compounds

, Volume 55, Issue 4, pp 654–657 | Cite as

Anti-Ache Benzylbenzofuran Derivatives from Silene conoidea

  • Rongrui Wei
  • Qinge MaEmail author
  • Guoyue Zhong
Article
  • 5 Downloads

A new benzylbenzofuran, named 5′,7-dihydroxy-6-propenyl-2-(11′,12′-dimethylpyran)-benzylbenzofuran (1), and seven known benzylbenzofuran derivatives (2–8) were isolated from Silene conoidea L. for the first time. The structures of compounds 1–8 were identified by their spectral data and reference data. Compounds 1–8 were evaluated for anti-acetylcholinesterase (AChE) activities for the first time. Compounds 1, 2, 5, and 6 showed anti-AChE activities with IC50 values ranging from 12.55–85.43 μM.

Keywords

Silene conoidea L. benzylbenzofuran anti-AChE 

Notes

Acknowledgment

This work was financially supported by the Key Scientific Research Project of Colleges and Universities in Henan Province (No. 19A350006), the National Natural Science Foundation of China (No. 81803843), the Standard Revision Research Project of National Pharmacopoeia Committee (No. 2018Z090), the Science and Technology Project of Jiangxi Health Commission (No. 20195648), the Science and Technology Project of Jiangxi Health Commission (No. 20195650), the Science and Technology Project of Jiangxi Provincial Department of Education (No. GJJ180662), the Science and Technology Project of Jiangxi Provincial Department of Education (No. GJJ180688), and the Scientific Research Project of First-class Discipline of Chinese Materia Medica of Jiangxi University of TCM (No. JXSYLXK-ZHYAO032).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Innovative Drugs and High Efficiency Energy Saving and Consumption Reduction Pharmaceutical Equipment, Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Key Laboratory of Modern Preparation of TCM of Ministry of EducationJiangxi University of Traditional Chinese MedicineNanchangP. R. China

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