Chemistry of Natural Compounds

, Volume 55, Issue 4, pp 654–657 | Cite as

Anti-Ache Benzylbenzofuran Derivatives from Silene conoidea

  • Rongrui Wei
  • Qinge MaEmail author
  • Guoyue Zhong

A new benzylbenzofuran, named 5′,7-dihydroxy-6-propenyl-2-(11′,12′-dimethylpyran)-benzylbenzofuran (1), and seven known benzylbenzofuran derivatives (2–8) were isolated from Silene conoidea L. for the first time. The structures of compounds 1–8 were identified by their spectral data and reference data. Compounds 1–8 were evaluated for anti-acetylcholinesterase (AChE) activities for the first time. Compounds 1, 2, 5, and 6 showed anti-AChE activities with IC50 values ranging from 12.55–85.43 μM.


Silene conoidea L. benzylbenzofuran anti-AChE 



This work was financially supported by the Key Scientific Research Project of Colleges and Universities in Henan Province (No. 19A350006), the National Natural Science Foundation of China (No. 81803843), the Standard Revision Research Project of National Pharmacopoeia Committee (No. 2018Z090), the Science and Technology Project of Jiangxi Health Commission (No. 20195648), the Science and Technology Project of Jiangxi Health Commission (No. 20195650), the Science and Technology Project of Jiangxi Provincial Department of Education (No. GJJ180662), the Science and Technology Project of Jiangxi Provincial Department of Education (No. GJJ180688), and the Scientific Research Project of First-class Discipline of Chinese Materia Medica of Jiangxi University of TCM (No. JXSYLXK-ZHYAO032).


  1. 1.
    Y. J. Yan, H. F. Xie, A. Gao, J. Gong, N. Li, Y. D. Chen, F. Lu, E. T. Hou, and S. F. Ni, J. Liaoning Univ. TCM, 13, 91 (2011).Google Scholar
  2. 2.
    Z. Ali, V. U. Ahmad, M. S. Ali, F. Iqbal, M. Zahid, and N. Alam, Nat. Prod. Res., 13, 121 (1999).Google Scholar
  3. 3.
    X. K. Zhang, Q. F. Xiong, G. S. Zhang, X. Q. Zhang, and X. Q. Cai, J. Changjiang. Veg., 21, 13 (2011).Google Scholar
  4. 4.
    P. H. Wei, X. M. Dong, and X. R. Chen, J. Shandong Educ. Inst., 2, 108 (2006).Google Scholar
  5. 5.
    K. Franke, A. Porzel, M. Masaoud, G. Adam, and J. Schmidt, Phytochemistry, 56, 611 (2001).CrossRefGoogle Scholar
  6. 6.
    F. A. Adem, V. Kuete, A. T. Mbaveng, M. Heydenreich, A. Ndakala, B. Irungu, T. Efferth, and A. Yenesew, Fitoterapia, 128, 26 (2018).CrossRefGoogle Scholar
  7. 7.
    Y. Ma, G. Q. Han, and Y. Y. Wang, Acta Pharm. Sin., 28, 370 (1993).Google Scholar
  8. 8.
    J. Feng and X. W. Yang, China J. Chin. Mater. Med., 34, 852 (2009).Google Scholar
  9. 9.
    O. A. Lima, O. R. Gottlieb, and M. T. Magalhaes, Phytochemistry, 11, 2031 (1972).CrossRefGoogle Scholar
  10. 10.
    Y. Ma and G. Q. Han, Acta Bot. Sin., 35, 687 (1993).Google Scholar
  11. 11.
    Q. G. Ma, R. R. Wei, W. M. Liu, Z. P. Sang, and X. H. Guo, Chem. Nat. Compd., 53, 949 (2017).CrossRefGoogle Scholar
  12. 12.
    X. R. Peng, X. Wang, J. R. Dong, X. J. Qin, Z. R. Li, H. Yang, L. Zhou, and M. H. Qiu, J. Agric. Food Chem., 65, 9453 (2017).CrossRefGoogle Scholar
  13. 13.
    Q. G. Ma, R. R. Wei, M. Yang, X. Y. Huang, F. Wang, Z. P. Sang, W. M. Liu, and Q. Yu, J. Agric. Food Chem., 66, 5540 (2018).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Innovative Drugs and High Efficiency Energy Saving and Consumption Reduction Pharmaceutical Equipment, Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Key Laboratory of Modern Preparation of TCM of Ministry of EducationJiangxi University of Traditional Chinese MedicineNanchangP. R. China

Personalised recommendations