An Efficient Synthetic Method for N-Alkylcytisines
Cytisine and its derivatives are attractive to many researchers because of their broad spectra of biological activity, e.g., spasmolytic, insecticidal, cholinergic, analgesic, etc. [1, 2, 3, 4, 5, 6, 7]. Therefore, the alkaloid cytisine and its derivatives are promising compounds for possible modification and design of new medicines based on them.
Herein the development of a convenient method for alkylating cytisine at the secondary amine is communicated. Compounds 1a,b were synthesized from cytisine and nonyl iodide and dodecyl bromide by heating the mixture at 150°C for 6 h. Prolonged refluxing in various solvents (DMSO, DMF, o-xylene) formed 1a,b in yields <20% with mixtures of unidentified side products.
The work was performed under State Task Topic AAAA-A17-117011910025-6 and was financially supported by the Russian Foundation for Basic Research (Grant No. 18-53-41004) and used equipment at Khimiya Common Use Center, Ufa Institute of Chemistry, Russian Academy of Sciences.
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