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Sinulaflexiolide P, A Cembrane-Type Diterpenoid from Bornean Soft Coral Sinularia flexibilis

  • Chin-Soon Phan
  • Chun-Sieng Yee
  • Charles Santhanaraju Vairappan
  • Takahiro Ishii
  • Takashi KamadaEmail author
Article
  • 12 Downloads

A new cembrane-type diterpenoid, sinulaflexiolide P (1), along with three known derivatives: sinulaflexiolide H (2), 11-epi-sinulariolide acetate (3), and (1S*,3S*,4S*,7E,11E)-3,4-epoxy-13-oxo-3,7,11,15-cembratriene (4), was isolated from a population of Bornean soft coral Sinularia flexibilis. The structures of these metabolites were elucidated based on spectroscopic data including NMR and HR-ESI-MS. In addition, these compounds were tested against six strains of marine fungi.

Keywords

Sinularia flexibilis soft coral diterpenoid cembrane antifungal 

Notes

Acknowledgment

This work was supported by the Sabah Biodiversity Centre (GL0070), the Fujiwara Natural History Foundation, Universiti Malaysia Sabah (GUG0089-SG-2/2016) and the Ministry of Higher Education, Malaysia (FRG0464-2017). The authors would like to thank Prof. Dr. Tatsufumi Okino and Ms. Liang Wei (Hokkaido University) for SciFinder Search as well as Prof. Dr. Hatai (Universiti Malaysia Sabah) for guidance and providing the fungal strains.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Chin-Soon Phan
    • 1
  • Chun-Sieng Yee
    • 1
  • Charles Santhanaraju Vairappan
    • 1
  • Takahiro Ishii
    • 2
  • Takashi Kamada
    • 3
    Email author
  1. 1.Institute for Tropical Biology and ConservationUniversiti Malaysia SabahKota KinabaluMalaysia
  2. 2.Department of Bioscience and Biotechnology, Faculty of AgricultureUniversity of the RyukyusOkinawaJapan
  3. 3.Department of Materials and Life Science, Faculty of Science and TechnologyShizuoka Institute of Science and TechnologyFukuroiJapan

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