Two New Sesterterpenes from Marine-Derived Fungus Arthrinium sp.

  • Bin Ye
  • Wangjing Ding
  • Pin-Mei Wang
  • Jinzhong XuEmail author

Two new sesterterpenes together with related known terpestacin were isolated from the cultural broth of a marine fungal strain (5XNZ5-4) that lives in the gut of a marine crab. The new compounds were identified on the basis of analyses of NMR and mass spectral data. This is the first report on the oxidative derivatives of terpestacin. The new compounds showed no activity in antibacterial and cytotoxicity assays.


marine fungi Arthrinium sp. terpestacin sesterterpene 



This work was supported by the Natural Science Foundation of China (NSFC Nos. 21102128 and 41406141). We thank Jianyang Pan (Pharmaceutical Informatics Institute, Zhejiang University) for performing the NMR spectrometry.


  1. 1.
    Y. Li, J. Wang, W. He, X. Lin, X. Zhou, and Y. Liu, Chem. Nat. Compd., 53, 373 (2017).CrossRefGoogle Scholar
  2. 2.
    M. Wei, R. Xu, S. Du, C. Wang, T. Xu, and C. Shao, Chem. Nat. Compd., 52, 1011 (2016).CrossRefGoogle Scholar
  3. 3.
    E. Vijayakumar, K. Roy, S. Chatterjee, S. K. Deshmukh, B. N. Ganguli, H. W. Fehlhaber, and H. Kogler, J. Org. Chem., 61 (19), 6591 (1996).CrossRefGoogle Scholar
  4. 4.
    J. Wang, Z. Wang, Z. Ju, J. Wan, S. Liao, X. Lin, T. Zhang, X. Zhou, H. Chen, Z. Tu, and Y. Liu, Planta Med., 81 (2), 160 (2015).CrossRefGoogle Scholar
  5. 5.
    J. Wang, X. Wei, X. Qin, X. Lin, X. Zhou, S. Liao, B. Yang, J. Liu, Z. Tu, and Y. Liu, Org. Lett., 17 (3), 656 (2015).CrossRefGoogle Scholar
  6. 6.
    A. M. Elissawy, S. S. Ebada, M. L. Ashour, F. C. Ozkaya, W. Ebrahim, A. B. Singab, and P. Proksch, Phytochem. Lett., 20, 246 (2017).CrossRefGoogle Scholar
  7. 7.
    S. S. Ebada, B. Schulz, V. Wray, F. Totzke, M. H. G. Kubbutat, W. E. G. Mueller, A. Hamacher, M. U. Kassack, W. Lin, and P. Proksch, Bioorg. Med. Chem., 19 (15), 4644 (2011).CrossRefGoogle Scholar
  8. 8.
    S. Iimura, M. Oka, Y. Narita, M. Konishi, H. Kakisawa, Q. Gao, and T. Oki, Tetrahedron Lett., 34 (3), 493 (1993).CrossRefGoogle Scholar
  9. 9.
    J. G. Ondeyka, R. G. Ball, M. L. Garcia, A. W. Dombrowski, G. Sabnis, G. J. Kaczorowski, D. L. Zink, G. F. Bills, M. A. Goetz, W. A. Schmalhofer, and S. B. Singh, Bioorg. Med. Chem. Lett., 5 (7), 733 (1995).CrossRefGoogle Scholar
  10. 10.
    M. Tsukada, M. Fukai, K. Miki, T. Shiraishi, T. Suzuki, K. Nishio, T. Sugita, M. Ishino, K. Kinoshita, K. Takahashi, M. Shiro, and K. Koyama, J. Nat. Prod., 74 (7), 1645 (2011).CrossRefGoogle Scholar
  11. 11.
    S. Bloor, J. Antibiot., 61 (8), 515 (2008).CrossRefGoogle Scholar
  12. 12.
    S. Iimura, M. Oka, Y. Narita, M. Kinish, H. Kakisawa, Q. Gao, and T. Oki, Tetrahedron Lett., 34 (3), 493 (1993).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Bin Ye
    • 1
  • Wangjing Ding
    • 1
  • Pin-Mei Wang
    • 1
  • Jinzhong Xu
    • 1
    Email author
  1. 1.Institute of Marine Biology, Ocean CollegeZhejiang UniversityZhejiangP. R. China

Personalised recommendations