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Antimicrobial and Antioxidant Potential of Berberisinol, a New Flavone from Berberis baluchistanica

  • Samreen PervezEmail author
  • Muhammad Saeed
  • Muhammad Shaiq Ali
  • Itrat Fatima
  • Haroon Khan
  • Irfan Ullah
Article
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A new flavone, berberisinol (1), has been isolated from the EtOAc fraction of the MeOH extract of Berberis baluchistanica, along with known compounds, palmatine (2), berberine (3), 8-oxoberberine (4), β-sitosterol (5), oleanolic acid (6), and gallic acid (7), isolated for the first time from this species. Spectroscopic techniques including two-dimensional NMR were used for structural elucidation. Berberisinol (1) showed significant antibacterial and antioxidant potential.

Keywords

antimicrobial antioxidant Berberis baluchistanica berberisinol 

Notes

Acknowledgment

We are grateful to Prof. Dr. Abdul Malik of HEJ Research Institute of Chemistry, University of Karachi for his help in structural elucidation of isolated compounds.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Samreen Pervez
    • 1
    Email author
  • Muhammad Saeed
    • 1
  • Muhammad Shaiq Ali
    • 2
  • Itrat Fatima
    • 2
  • Haroon Khan
    • 3
  • Irfan Ullah
    • 4
  1. 1.Department of PharmacyUniversity of PeshawarPeshawarPakistan
  2. 2.H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological SciencesUniversity of KarachiKarachiPakistan
  3. 3.Department of Pharmacy Abdul Wali Khan University MardanMardanPakistan
  4. 4.Department of PharmacySarhad University of Science and Information TechnologyPeshawarPakistan

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