Determination of the Inhibitory Activity of Ferula sinkiangensis Polysaccharides for Protein Tyrosine Phosphatase 1B
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Polysaccharide fractions were sequentially extracted in 28.86 wt% yield from roots of Ferula sinkiangensis K. M. Shen. The polysaccharide fractions from F. sinkiangensis were identified as heteropolysaccharides and contained primarily the monosaccharides glucuronic and galacturonic acids, rhamnose, xylose, arabinose, galactose, and fructose. The isolated polysaccharide fractions at low concentrations exhibited in vitro inhibitory activity for protein-tyrosine phosphatase 1B. The degree of inhibition correlated with the galactose content in the polysaccharide fractions.
KeywordsFerula sinkiangensis K. M. Shen polysaccharides HPTLC protein-tyrosine phosphatase 1B (PTP1B) inhibitor
The research was financially supported by the Major Special Project of National Science and Technology, Research and Development of New Ethnic Drug Varieties and Its Key Innovation Technology (2017ZX09301045) and Tianshan Excellence Project in 2017-47 in addition to the Central Asia Drug Research and Development Center of the Chinese Academy of Sciences.