Flavanones and Flavones from Bashkir Propolis
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Propolis is a product of the honey bee Apis mellifera and has a broad spectrum of biological activity (antimicrobial, antifungal, antitumor, antineurodegenerative, anti-inflammatory, antioxidant, cytotoxic, antituberculosis, antiviral, and immunomodulating ) that is widely employed in traditional [2, 3] and folk medicine .
The chemical composition of Bashkir propolis produced by A. mellifera from plants of the southern Urals (Bashkiria) was studied by us for the first time. Pure flavanones 1–4 and flavones 5 and 6 were isolated and identified.
The work was financially supported by the Russian Foundation for Basic Research and the Academy of Sciences of the Republic of Bashkortostan (Project No. 17-43-020483 p_a). Structures of compounds were established using PMR and 13C NMR spectra with 2D experiments (COSY, HSQC, HMBC, NOESY) and MALDI TOF/TOF mass spectra obtained at the Agidel Common Use Center at the IPC, RAS.
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