Chemistry of Natural Compounds

, Volume 54, Issue 2, pp 305–309 | Cite as

Addition of Cyanoethyl Groups to Ring a of Triterpenoids

  • N. V. Galaiko
  • I. A. Tolmacheva
  • E. V. Igosheva
  • O. V. Savinova
  • V. V. Grishko
Article
  • 9 Downloads

The potential for cyanoethylation of ring A of triterpenoids and their A-seco derivatives prepared from allobetulone and methyl betulonate was investigated. Triterpenoids with a cyanoethyl moiety on C-1, C-2, and C-3 and derivatives with two cyanoethyl groups on ring A were synthesized. The inhibitory activity of the synthesized compounds for herpes simplex virus type 1 was studied in vitro.

Keywords

triterpenoids A-seco-triterpenoids betulin cyanoethylation acrylonitrile antiviral activity herpes simplex virus type 1 

Notes

Acknowledgment

The work was financially supported by the Government of Perm Krai in the framework of Science Project No. C-26/056, grants MK-5386.2016.3, RFBR No. 16-53-00029Bel_a and BRFBR No. M16R-012.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • N. V. Galaiko
    • 1
  • I. A. Tolmacheva
    • 1
  • E. V. Igosheva
    • 1
  • O. V. Savinova
    • 2
  • V. V. Grishko
    • 1
  1. 1.Institute of Technical Chemistry, Ural BranchRussian Academy of SciencesPermRussia
  2. 2.The Republican Research and Practical Center for Epidemiology and MicrobiologyMinistry of Health of the Republic of BelarusMinskBelarus

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