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An Expeditious Ultrasound-Initiated Green Synthesis of 1,2,4-Thiadiazoles in Water

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A convenient, environmentally benign, metal- and catalyst-free protocol has been developed for the conversion of thioamides to the corresponding 1,2,4-thiadiazole derivatives with chloranil under ultrasound irradiation in water at room temperature. This paper describes a general procedure for the synthesis of different 1,2,4-thiadiazoles in excellent yield in short reaction time via sonochemistry.

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Figure 1.
Scheme 1.

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Correspondence to Vandana Srivastava.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2020, 56(1), 123–126

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Chauhan, S., Verma, P., Mishra, A. et al. An Expeditious Ultrasound-Initiated Green Synthesis of 1,2,4-Thiadiazoles in Water. Chem Heterocycl Comp (2020). https://doi.org/10.1007/s10593-020-02632-5

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Keywords

  • aqueous medium
  • heterocycles
  • metal- and catalyst-free
  • one-pot synthesis
  • oxidative coupling
  • ultrasound irradiation