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Tetrahydroisoquinoline-Based Non-Peptidomimetic Plasmepsin Inhibitors

A series of tetrahydroisoquinoline derivatives containing different aryl substituents were designed and synthesized using Pictet–Spengler reaction as the key step. The synthesized tetrahydroisoquinoline derivatives displayed micromolar inhibitory activity against plasmepsins I and II.

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Correspondence to Linda Kinena.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2020, 56(1), 60–66

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Kinena, L., Ozola, V. Tetrahydroisoquinoline-Based Non-Peptidomimetic Plasmepsin Inhibitors. Chem Heterocycl Comp (2020). https://doi.org/10.1007/s10593-020-02623-6

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Keywords

  • plasmepsins
  • tetrahydroisoquinoline
  • malaria
  • Pictet–Spengler reaction
  • X-ray analysis