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Synthesis and characterization of new pyrido- and pyrazolopyrimidine derivatives using 2-substituted vinamidinium salts

  • Abdolmohammad MehranpourEmail author
  • Sedigheh Hashemnia
  • Mona Bornak
Article
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Several novel pyrido- and pyrazolopyrimidine derivatives were readily synthesized by reaction of 6-aminouracil or 3(5)-aminopyrazole with 2-substituted vinamidinium salts. The reactions were carried out in a relatively short time without any base or catalyst. The structures of the synthesized compounds were confirmed by UV-vis, IR, and 1H and 13C NMR spectroscopy, as well as mass spectrometry and elemental analysis. The obtained results showed that tautomers of 3(5)-amino-1(H)-pyrazole can participate in the formation of the new pyrido- and pyrazolopyrimidine derivatives with their respective most nucleophilic centers N-2 and C-4.

Keywords

pyrazolo[3,4-b]pyridine pyrazolo[1,5-a]pyrimidine pyrido[2,3-d]pyrimidine vinamidinium salts 

Notes

Financial support of this work by the Research Council of the Persian Gulf University is gratefully acknowledged.

Supplementary material

10593_2019_2582_MOESM1_ESM.pdf (2.7 mb)
ESM 1 (PDF 2797 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Abdolmohammad Mehranpour
    • 1
    Email author
  • Sedigheh Hashemnia
    • 1
  • Mona Bornak
    • 1
  1. 1.Chemistry Department, Faculty of SciencesPersian Gulf UniversityBushehrIran

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