Chemistry of Heterocyclic Compounds

, Volume 55, Issue 9, pp 851–855 | Cite as

Three-Component Condensation of 4-Imino-1-Phenylimidazolidin-2-One with Aldehydes and Meldrum's Acid: Synthesis of Imidazo[4,5-b]Pyridine-2,5(4H,6H)-Diones and 5-Substituted 1-Phenylhydantoins

  • Constantine S. Krylov
  • Andrey N. KomogortsevEmail author
  • Boris V. Lichitsky
  • Artem N. Fakhrutdinov
  • Arkady А. Dudinov
  • Mikhail M. Krayushkin

A convenient method for the synthesis of previously unknown imidazo[4,5-b]pyridine-2,5(4H,6H)-diones has been developed, based on a three-component condensation of 4-imino-1-phenylimidazolidin-2-one with aldehydes and Meldrum's acid. The possibility of accessing 5-substituted 1-phenylhydantoins based on the acid hydrolysis of imidazo[4,5-b]pyridine-2,5(4H,6H)-diones was shown.


aldehydes imidazo[4,5-b]pyridine-2,5(4H,6H)-diones 4-imino-1-phenylimidazolidin-2-one Meldrum's acid 5-substituted 1-phenylhydantoins three-component condensation 


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Constantine S. Krylov
    • 1
  • Andrey N. Komogortsev
    • 1
    Email author
  • Boris V. Lichitsky
    • 1
  • Artem N. Fakhrutdinov
    • 1
  • Arkady А. Dudinov
    • 1
  • Mikhail M. Krayushkin
    • 1
  1. 1.N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of SciencesMoscowRussia

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