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Chemistry of Heterocyclic Compounds

, Volume 55, Issue 8, pp 788–791 | Cite as

Synthesis of N-substituted 2-aminomethyl-5-methyl-7-phenyloxazolo[5,4-b]pyridines

  • Irina V. Palamarchuk
  • Mariya V. Matsukevich
  • Ivan V. KulakovEmail author
  • Tulegen М. Seilkhanov
  • Aleksander S. Fisyuk
Article
  • 22 Downloads

2-(Chloromethyl)-5-methyl-7-phenyloxazolo[5,4-b]pyridine was obtained by intramolecular cyclization based on the previously synthesized 2-chloro-N-(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)acetamide. The possibility of its use in the synthesis of previously unknown 2-aminomethyloxazolo[5,4-b]pyridine derivatives by nucleophilic substitution with various amines and a cyclic amide has been shown.

Keywords

2-aminomethyloxazolo[5,4-b]pyridine derivatives 3-amino-4-phenylpyridin-2(1Н)-one chloroacetamide, oxazolo[5,4-b]-pyridine intramolecular cyclization nucleophilic substitution 

Notes

The study was carried out with the financial support of the Russian Foundation for Basic Research within the framework of research project No. 18-33-01143.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Irina V. Palamarchuk
    • 1
  • Mariya V. Matsukevich
    • 2
  • Ivan V. Kulakov
    • 1
    Email author
  • Tulegen М. Seilkhanov
    • 3
  • Aleksander S. Fisyuk
    • 2
    • 4
  1. 1.Institute of ChemistryUniversity of TyumenTyumenRussia
  2. 2.F. M. Dostoevsky Omsk State UniversityOmskRussia
  3. 3.Sh. Ualikhanov Kokshetau State UniversityKokshetauKazakhstan
  4. 4.Omsk State Technical UniversityOmskRussia

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