Chemistry of Heterocyclic Compounds

, Volume 55, Issue 8, pp 773–778 | Cite as

Synthesis and Antimicrobial Activity of Novel Polycyclic Thienopyridazine Derivatives

  • Ahmed A. Fayed
  • Mahmoud N. M. Yousif
  • Taha T. Abdelgawad
  • Abd El-Galil E. AmrEmail author
  • Nabil M. Yousif
  • Farouk A. Gad

A series of novel thienopyridazine derivatives has been synthesized using 9-aminodibenzo[f,h]thieno[2,3-c]cinnoline-8-carbonitrile as starting material. The target products exhibit promising antibacterial and antifungal properties against bacterial strains E. coli, S. aureus, B. subtilis, and K. pneumoniae and fungal strains A. fumigatus and C. albicans. The highest antimicrobial activity against all tested microorganisms demonstrate pyridothienocinnoline derivatives.


pyridothienocinnoline pyrimidothienocinnoline thiazinothienocinnoline thiazolopyrimidothienocinnoline thienocinnoline thienopyridazine triazolopyrimidothienocinnoline antimicrobial agent 


The authors are grateful to the Deanship of Scientific Research of King Saud University for funding in frame of Vice Deanship of Scientific Research Chairs.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Ahmed A. Fayed
    • 1
    • 2
  • Mahmoud N. M. Yousif
    • 2
  • Taha T. Abdelgawad
    • 1
    • 3
  • Abd El-Galil E. Amr
    • 4
    • 5
    Email author
  • Nabil M. Yousif
    • 2
  • Farouk A. Gad
    • 2
  1. 1.Department of Respiratory Therapy, Faculty of Medical Rehabilitation SciencesTaibah UniversityMadinahSaudi Arabia
  2. 2.National Research CenterCairoEgypt
  3. 3.Department of Chest Medicine, Faculty of MedicineMansoura UniversityMansouraEgypt
  4. 4.Department of Pharmaceutical Chemistry, Drug Exploration and Development ChairCollege of Pharmacy, King Saud UniversityRiyadhSaudi Arabia
  5. 5.Applied Organic Chemistry Department, National Research CenterCairoEgypt

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