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Chemistry of Heterocyclic Compounds

, Volume 55, Issue 8, pp 692–694 | Cite as

Open image in new window Saturated spirocyclic nitrogen-containing heterocycles with gem-difluorocycloalkane moieties (microreview)

  • Oleksandr O. GrygorenkoEmail author
  • Kostiantyn P. Melnykov
Article
  • 18 Downloads

Recent advances in synthetic and medicinal chemistry of saturated spirocyclic nitrogen-containing heterocycles with gem-difluorocycloalkane moieties are surveyed, including results published in the last decade. In particular, gem-difluoro-substituted derivatives of azaspiro[2.n]alkanes, azaspiro[3.n]alkanes, azaspiro[4.5]decane, and other spirocyclic scaffolds are discussed.

Notes

Financial support from Enamine Ltd. is acknowledged. The authors thank Prof. Andrey A. Tolmachev for his encouragement and support.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Oleksandr O. Grygorenko
    • 1
    • 2
    Email author
  • Kostiantyn P. Melnykov
    • 1
    • 2
  1. 1.Enamine Ltd.KyivUkraine
  2. 2.Taras Shevchenko National University of KyivKyivUkraine

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