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Chemistry of Heterocyclic Compounds

, Volume 55, Issue 4–5, pp 473–477 | Cite as

Synthesis and halocyclization of 2-mercaptonicotinic acid propargyl derivatives

  • Elena V. KalitaEmail author
  • Dmitry G. Kim
  • Oleg S. Eltsov
  • Taisiya S. Shtukina
  • Irina V. Mukhametgaleeva
Article
  • 13 Downloads

Alkylation of 2-sulfanylpyridine-3-carboxylic acid with 3-bromo-1-propyne proceeds with the formation of 2-(prop-2-yn-1-ylsulfanyl)-pyridine-3-carboxylic acid and prop-2-yn-1-yl 2-(prop-2-yn-1-ylsulfanyl)pyridine-3-carboxylate, which react with bromine and iodine to form 2,3-dihydro[1,3]thiazolo[3,2-a]pyridinium systems.

Keywords

prop-2-yn-1-yl 2-(prop-2-yn-1-ylsulfanyl)pyridine-3-carboxylate 2-(prop-2-yn-1-ylsulfanyl)pyridine-3-carboxylic acid 3-halomethylidene-8-carboxy-2,3-dihydro[1,3]thiazolo[3,2-a]pyridin-4-ium trihalide and halide 3-iodomethylidene-8-[(2,3-diiodoprop-2-en-1-yl)oxy]carbonyl-2,3-dihydro[1,3]thiazolo[3,2-a]pyridin-4-ium triiodide halocyclization 

Notes

This work was supported by the Government of the Russian Federation (Decree No. 211 of March 16, 2013, Agreement No. 02.A03.21.0011) and as part of the fulfillment of the State Assignment of the Ministry of Education and Science of the Russian Federation (4.9665.2017/8.9).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Elena V. Kalita
    • 1
    Email author
  • Dmitry G. Kim
    • 1
  • Oleg S. Eltsov
    • 2
  • Taisiya S. Shtukina
    • 2
  • Irina V. Mukhametgaleeva
    • 1
  1. 1.South Ural State UniversityChelyabinskRussia
  2. 2.Ural Federal University named after the first President of Russia B. N. YeltsinYekaterinburgRussia

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