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Chemistry of Heterocyclic Compounds

, Volume 55, Issue 4–5, pp 442–447 | Cite as

Multicomponent synthesis and molecular structure of 3-amino-2-aroyl(alkoxycarbonyl, arylcarbamoyl)-4-aryl(hetaryl)-5-arylcarbamoyl-6-methylthieno[2,3-b]pyridines

  • Ivan V. Dyachenko
  • Vladimir D. Dyachenko
  • Pavel V. Dorovatovskii
  • Victor N. Khrustalev
  • Valentine G. NenajdenkoEmail author
Article
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A new, effective method has been developed for the synthesis of functionalized thieno[2,3-b]pyridines by multicomponent condensation reactions of aromatic and heteroaromatic aldehydes, cyanothioacetamide, acetoacetanilides, and alkylating agents containing activated methylene groups. The structures of 3-amino-2-benzoyl-4-(furan-2-yl)-6-methyl-N-phenylthieno[2,3-b]pyridine-5-carboxamide, 3-amino-N2-(4-bromophenyl)-N5-(4-chlorophenyl)-6-methyl-4-(3-methylthiophen-2-yl)thieno[2,3-b]pyridine-2,5-dicarboxamide, and 3-amino- 4-(2-chlorophenyl)-N-(4-chlorophenyl)-6-methyl-2-(4-methylbenzoyl)thieno[2,3-b]pyridine-5-carboxamide were studied by X-ray structural analysis.

Keywords

acetoacetanilides alkylating reagents aromatic aldehydes cyanothioacetamide thieno[2,3-b]pyridines X-ray structural analysis 

Notes

This work received financial support from the Ministry of Education and Science of the Russian Federation (Project No. 4.1154.2017/4.6).

Supplementary material

10593_2019_2477_MOESM1_ESM.pdf (645 kb)
ESM 1 (PDF 644 kb)

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Ivan V. Dyachenko
    • 1
  • Vladimir D. Dyachenko
    • 1
  • Pavel V. Dorovatovskii
    • 2
  • Victor N. Khrustalev
    • 3
  • Valentine G. Nenajdenko
    • 4
    Email author
  1. 1.Luhansk Taras Shevchenko National UniversityLuhanskUkraine
  2. 2.National Research Center “Kurchatov Institute”MoscowRussia
  3. 3.RUDN UniversityMoscowRussia
  4. 4.Lomonosov Moscow State UniversityMoscowRussia

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