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Chemistry of Heterocyclic Compounds

, Volume 55, Issue 4–5, pp 401–407 | Cite as

8-(Methyl(phenyl)sulfonyl)-2,6-dihydroimidazo[1,2-c]- pyrimidin-5(3Н)-ones and 9-(methyl(phenyl)sulfonyl)- 2,3,4,7-dihydro-6H-pyrimido[1,6-a]pyrimidin-6-ones: synthesis and antiviral activity

  • Roman N. Solomyannyi
  • Olga V. Shablykina
  • Viktoriia S. MoskvinaEmail author
  • Volodymir P. Khilya
  • Eduard B. Rusanov
  • Vladimir S. Brovarets
Article
  • 5 Downloads

A convenient method for the synthesis of novel sulfonic cytosine derivatives, 8-(methyl(phenyl)sulfonyl)-2,6-dihydroimidazo[1,2-c]-pyrimidin-5(3Н)-ones and 9-(methyl(phenyl)sulfonyl)-2,3,4,7-tetrahydro-6H-pyrimido[1,6-a]pyrimidin-6-ones, has been developed based on the reaction of 3-amino-2-(methyl(phenyl)sulfonyl)acrylonitriles with 2-chloroethyl isocyanate and 3-chloropropyl isocyanate. The resulting heteryl sulfones possess antiviral activity.

Keywords

3-amino-2-(methyl(phenyl)sulfonyl)acrylonitriles 8-(methyl(phenyl)sulfonyl)-2,6-dihydroimidazo[1,2-c]pyrimidin-5(3Н)-ones 9-(methyl(phenyl)sulfonyl)-2,3,4,7-tetrahydro-6H-pyrimido[1,6-a]pyrimidin-6-ones heterocyclization antiviral activity 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Roman N. Solomyannyi
    • 1
  • Olga V. Shablykina
    • 1
    • 2
  • Viktoriia S. Moskvina
    • 1
    • 2
    Email author
  • Volodymir P. Khilya
    • 2
  • Eduard B. Rusanov
    • 3
  • Vladimir S. Brovarets
    • 1
  1. 1.V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of UkraineKyivUkraine
  2. 2.Kyiv Taras Shevchenko National UniversityKyivUkraine
  3. 3.Institute of Organic Chemistry of the National Academy of Sciences of UkraineKyivUkraine

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