Chemistry of Heterocyclic Compounds

, Volume 55, Issue 4–5, pp 397–400 | Cite as

Pyrrolo[2,3-d]pyrimidine derivatives in the synthesis of a novel heterocyclic system 2a,5a,7-triazaacenaphthylene

  • Lyubov V. Muzychka
  • Iryna O. Yaremchuk
  • Evgenii V. Verves
  • Oleg B. SmoliiEmail author

A convenient method for the synthesis of methyl 8-oxo-3H,8H-2a,5a,7-triazaacenaphthylene-2-carboxylate by iodination of 7-allyl-4-methoxypyrrolo[2,3-d]pyrimidine-6-carboxylic acid methyl ester followed by elimination of hydrogen iodide has been developed. The use of 4-methoxypyrrolo[2,3-d]pyrimidine-6-carboxylic acid as the starting compound led to the formation of iodomethylpyrimido[5',4':4,5]-pyrrolo[2,1-c][1,4]oxazine, a promising precursor for the synthesis of a new tricyclic system based on pyrrolo[2,3-d]pyrimidine.


pyrimido[5',4':4,5]pyrrolo[2,1-c][1,4]oxazine pyrrolo[2,3-d]pyrimidine 2a,5a,7-triazaacenaphthylene cyclization iodination 


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Lyubov V. Muzychka
    • 1
  • Iryna O. Yaremchuk
    • 1
  • Evgenii V. Verves
    • 1
  • Oleg B. Smolii
    • 1
    Email author
  1. 1.V. P. Kukhar Institute of Bioorganic Chemistry and PetrochemistryNational Academy of Sciences of UkraineKyivUkraine

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