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Chemistry of Heterocyclic Compounds

, Volume 55, Issue 4–5, pp 386–391 | Cite as

Synthesis of 7-arylimidazo[1,2-a]pyrazin-8(7H)-one derivatives

  • Svitlana S. Kovalenko
  • Oleksandr G. DrushlyakEmail author
  • Sergiy M. Kovalenko
  • Natalya D. Bunyatyan
  • Dmitry V. Kravchenko
  • Alexandre V. Ivachtchenko
Article
  • 10 Downloads

A suitable approach to the synthesis of 7-arylimidazo[1,2-a]pyrazin-8(7H)-ones starting from esters of oxalic acid monoamides via cyclization of intermediate 3-aminopyrazin-2-ones with α-halocarbonyl compounds has been suggested.

Keywords

3-aminopyrazin-2(1H)-one 2-halophenylethanone imidazo[1,2-a]pyrazin-8(7H)-one 3-methoxypyrazin-2(1H)-one pyrazine-2,3-dione cyclization 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Svitlana S. Kovalenko
    • 1
  • Oleksandr G. Drushlyak
    • 1
    Email author
  • Sergiy M. Kovalenko
    • 2
  • Natalya D. Bunyatyan
    • 3
    • 4
  • Dmitry V. Kravchenko
    • 5
  • Alexandre V. Ivachtchenko
    • 6
  1. 1.National University of PharmacyKharkivUkraine
  2. 2.V. N. Karazin Kharkiv National UniversityKharkivUkraine
  3. 3.I. M. Sechenov First Moscow State Medical University (Sechenovskiy University)MoscowRussia
  4. 4.Scientific Centre for Expert Evaluation of Medicinal ProductsMoscowRussia
  5. 5.Chemical Diversity Research InstituteKhimkiRussia
  6. 6.ChemDiv, Inc.San DiegoUSA

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