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Chemistry of Heterocyclic Compounds

, Volume 55, Issue 4–5, pp 379–385 | Cite as

N-Boc-4-aminopyrazole-5-carbaldehydes in Friendländer synthesis of pyrazolo[4,3-b]pyridines

  • Georgiy G. YakovenkoEmail author
  • Oleh A. Lukianov
  • Andriy V. Bol’but
  • Mykhailo V. Vovk
Article
  • 22 Downloads

N-Boc-4-aminopyrazole-5-carbaldehydes reacted with aryl, hetaryl, alkyl, and cycloalkyl ketones containing methylene groups. The reactions were accomplished in refluxing acetic acid in the presence of pyrrolidine and resulted in the formation of 5-substituted and carbo[b]fused pyrazolo[4,3-b]pyridines.

Keywords

4-aminopyrazole-5-carbaldehydes ketones pyrazolo[4,3-b]pyridines Friendländer reaction 

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Authors and Affiliations

  • Georgiy G. Yakovenko
    • 1
    • 2
    Email author
  • Oleh A. Lukianov
    • 2
  • Andriy V. Bol’but
    • 2
    • 3
  • Mykhailo V. Vovk
    • 2
  1. 1.National University “Kyiv-Mohyla Academy”KyivUkraine
  2. 2.Institute of Organic ChemistryNational Academy of Sciences of UkraineKyivUkraine
  3. 3.Enamine Ltd.KyivUkraine

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