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Chemistry of Heterocyclic Compounds

, Volume 54, Issue 12, pp 1161–1167 | Cite as

Microwave-assisted Cu-catalyzed C–C bond formation: one-pot synthesis of fully substituted 1,2,3-triazoles using nonsymmetrical iodoalkynes and their biological evaluation

  • Sirassu Narsimha
  • Kumara Swamy Battula
  • Yellu Narasimha Reddy
  • Vasudeva Reddy NagavelliEmail author
Article

A copper-catalyzed one-pot synthesis of fused benzothiazino[1,2,3]triazolo[4,5-c]quinolinone derivatives from 1-iodoalkynes with different aryl azides via an in situ generated 5-iodotriazole intermediate in [BMIM]PF6 under microwave irradiation is reported. The reaction provided the desired fused 1,2,3-triazoles in good to excellent yields. Anticancer activity of the synthesized compounds has been screened in vitro against different cancer cell lines (MCF-7, HeLa, A-549, and IMR-32). Some of the derivatives showed remarkable anticancer activity against two cancer cell lines – MCF-7 and A-549. The remaining compounds have shown good to moderate activity against tested cell lines.

Keywords

fused 1,2,3-triazole ionic liquids anticancer activity microwave irradiation 

Notes

The authors are thankful to the Director of Indian Institute of Chemical Technology in Hyderabad for recording 1H, 13C NMR and mass spectra. S. Narsimha thanks Council of Scientific and Industrial Research, New Delhi, for the award of senior research fellowship.

Supplementary material

10593_2019_2408_MOESM1_ESM.pdf (6.3 mb)
ESM 1 (PDF 6444 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Sirassu Narsimha
    • 1
  • Kumara Swamy Battula
    • 1
  • Yellu Narasimha Reddy
    • 2
  • Vasudeva Reddy Nagavelli
    • 1
    Email author
  1. 1.Department of ChemistryKakatiya UniversityWarangalIndia
  2. 2.Department of Pharmacology and ToxicologyKakatiya UniversityWarangalIndia

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