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Chemistry of Heterocyclic Compounds

, Volume 54, Issue 12, pp 1111–1116 | Cite as

Facile one-pot synthesis of N-fused 1,2,4-triazoles via oxidative cyclization using manganese dioxide

  • Ashish BhattEmail author
  • Rajesh K. Singh
  • Ravi Kant
Article
  • 17 Downloads

A facile one-pot synthesis of N-fused 1,2,4-triazoles from heterocyclic hydrazines and aldehydes is reported. The reaction is efficiently promoted by manganese dioxide to afford the desired products mostly in high yields and in relatively short times. The mild nature of the synthesis, cheap oxidizing agent, and short reaction time are notable advantages of the developed protocol. This protocol is effective toward various substrates having different functionalities.

Keywords

manganese dioxide toluene 1,2,4-triazole [1,2,4]triazolo[4,3-a]pyrazine [1,2,4]triazolo[4,3-b]pyridazine [1,2,4]triazolo[4,3-a]pyridine [1,2,4]triazolo[4,3-a]pyrimidine 

Notes

Supplementary material

10593_2019_2400_MOESM1_ESM.pdf (9 mb)
ESM 1 (PDF 9196 kb)

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Authors and Affiliations

  1. 1.Department of ChemistryMewar UniversityChittorgarhIndia
  2. 2.Department of PharmacyMewar UniversityChittorgarhIndia

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