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Chemistry of Heterocyclic Compounds

, Volume 54, Issue 9, pp 859–867 | Cite as

Reactions of 2Н(4Н)-chromenes with dinucleophiles: one-step synthesis of 2-(1H-(bi)pyrazol-3-yl)- and 2-(1,4(5)-(benzo)diazepin-4-yl)phenols

  • Serhii P. Zahorulko
  • Svetlana А. Varenichenko
  • Oleg K. Farat
  • Aleksander V. Mazepa
  • Sergiy I. Okovytyy
  • Victor I. Markov
Article
  • 20 Downloads

Novel derivatives of 2-(1H-(bi)pyrazol-3-yl)phenols and 2-(1,4(5)-(benzo)diazepin-4-yl)phenols were obtained in the reaction of (4-amino-2H-chromen-2-ylidene)malondialdehyde and 4H-chromen-4-imines with 1,2-, 1,3-, and 1,4-dinucleophiles proceeding as a cascade reaction initiated by the Michael reaction.

Keywords

chromenes dipyrazoles dinucleophiles rearrangement Vilsmeier–Haack reagent 

Notes

This work was financially supported by the Ministry of Education and Science of Ukraine under the state budget theme No. 0115U003159 “New synthetic methods for the design of nitrogen- and sulfur-containing biologically active compounds”.

Supplementary material

10593_2018_2367_MOESM1_ESM.pdf (3 mb)
ESM 1 (PDF 3107 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Serhii P. Zahorulko
    • 1
  • Svetlana А. Varenichenko
    • 1
  • Oleg K. Farat
    • 2
  • Aleksander V. Mazepa
    • 3
  • Sergiy I. Okovytyy
    • 4
  • Victor I. Markov
    • 1
  1. 1.Ukrainian State University of Chemical TechnologyDniproUkraine
  2. 2.Moscow M. V. Lomonosov State UniversityMoscowRussia
  3. 3.A. V. Bogatsky Physico-Chemical InstituteNational Academy of Sciences of UkraineOdessaUkraine
  4. 4.Oles Honchar Dnipro National UniversityDniproUkraine

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