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Chemistry of Heterocyclic Compounds

, Volume 54, Issue 9, pp 887–891 | Cite as

Studies on quinazolines 7*. Alkylation of 2-aryl-4,4-diphenyl-3,4-dihydroquinazolines with methyl iodide

  • Elena V. Gromachevskaya
  • Elena А. Kaigorodova
  • Leonid D. Konyushkin
  • Gennady D. Krapivin
Article
  • 7 Downloads

The reaction of 2-aryl-4,4-diphenyl-3,4-dihydroquinazoline with methyl iodide in acetone in the presence of potassium hydroxide at 40°C leads to the formation of the corresponding 1-methyl-4,4-diphenyl-1,4-dihydroquinazolines and 1,3-dimethyl-4,4-diphenyl-1,4-dihydroquinazolin-3-ium iodides. The structure of 2-(7-methoxy-1,3-benzodioxol-5-yl)-1-methyl-4,4-diphenyl-1,4-dihydroquinazoline was established by heteronuclear correlation NMR spectroscopy.

Keywords

1,3-dimethyl-4,4-diphenyl-1,4-dihydroquinazolin-3-ium iodides 1-methyl-4,4-diphenyl-1,4-dihydroquinazolines methyl iodide alkylation 

Notes

The study was carried out with the financial support of the Ministry of Education and Science of the Russian Federation (grant 4.6087.2017/БЧ).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Elena V. Gromachevskaya
    • 1
  • Elena А. Kaigorodova
    • 2
  • Leonid D. Konyushkin
    • 3
  • Gennady D. Krapivin
    • 1
  1. 1.Kuban State Technological UniversityKrasnodarRussia
  2. 2.Kuban State Agrarian UniversityKrasnodarRussia
  3. 3.N. D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussia

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