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Chemistry of Heterocyclic Compounds

, Volume 54, Issue 8, pp 789–795 | Cite as

Synthesis of 5-hydroxy- and 5-sulfanyl-substituted [1,2,3]triazolo[4,5-е][1,4]diazepines

  • Sergiy V. Kemskiy
  • Natalia A. Syrota
  • Andriy V. Bol’but
  • Viktor I. Dorokhov
  • Mykhaylo V. Vovk
Article
  • 43 Downloads

5-Amino-N-(2,2-dimethoxyethyl)-1Н-1,2,3-triazole-4-carboxamides in formic acid were subjected to intramolecular cyclization to 5-hydroxy[1,2,3]triazolo[4,5-е][1,4]diazepines, which were converted by treatment with S-nucleophiles to 5-thio-functionalized derivatives.

Keywords

5-amino-N-(2,2-dimethoxyethyl)-1Н-1,2,3-triazole-4-carboxamides [1,2,3]triazolo[4,5-е][1,4]diazepines intramolecular cyclization thiofunctionalization 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Sergiy V. Kemskiy
    • 1
  • Natalia A. Syrota
    • 2
  • Andriy V. Bol’but
    • 1
    • 3
  • Viktor I. Dorokhov
    • 1
  • Mykhaylo V. Vovk
    • 1
  1. 1.Institute of Organic ChemistryNational Academy of Sciences of UkraineKyivUkraine
  2. 2.National University of Kyiv-Mohyla AcademyKyivUkraine
  3. 3.Enamine Ltd.KyivUkraine

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