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Chemistry of Heterocyclic Compounds

, Volume 54, Issue 6, pp 669–672 | Cite as

Effective synthesis of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines

  • Alexander S. Kulikov
  • Margarita A. Epishina
  • Leonid L. Fershtat
  • Nina N. Makhova
Article
  • 30 Downloads

A highly effective method for the preparation of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines was developed on the basis of condensation reaction between aryl(hetaryl) α-bromo ketones and commercially available thiocarbohydrazide, followed by treatment of the obtained 2-hydrazinyl-6H-1,3,4-thiadiazine hydrobromides with ortho esters in the presence of trifluoroacetic acid under mild conditions.

Keywords

α-bromo ketones hydrazinylthiadiazines ortho esters thiocarbohydrazide 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines condensation 

Notes

Supplementary material

10593_2018_2325_MOESM1_ESM.pdf (1.9 mb)
ESM 1 (PDF 1951 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Alexander S. Kulikov
    • 1
  • Margarita A. Epishina
    • 1
  • Leonid L. Fershtat
    • 1
  • Nina N. Makhova
    • 1
  1. 1.N. D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussia

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