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Chemistry of Heterocyclic Compounds

, Volume 54, Issue 6, pp 658–663 | Cite as

Microwave-assisted synthesis of novel benzodifuran-based bis(N-(het)arylthiazol-2-amine) derivatives and their antibacterial and antimycobacterial activities

  • N. H. Kumar Baba
  • Dongamanti Ashok
  • Boddu Ananda Rao
  • Madderla Sarasija
  • Nandula Y. S. Murthy
Article
  • 24 Downloads

A new series of 4,4'-(3,5-diphenethylbenzo[1,2-b:5,4-b']difuran-2,6-diyl)bis(N-(het)arylthiazol-2-amine) derivatives have been synthesized from 1,1'-(3,5-diphenethylbenzo[1,2-b:5,4-b']difuran-2,6-diyl)diethanone O,O'-diacetyl dioxime and substituted isothiocyanates under conventional and microwave irradiation conditions. The obtained products were subjected to in vitro antibacterial and antimycobacterial activity tests. Some of the compounds exhibited noteworthy antibacterial activity against Bacillus subtilis (+ve) and Pseudomonas aeruginosa (-ve) strains and antimycobacterial activity against Mycobacterium bovis strain.

Keywords

benzodifuran thiazole antibacterial antimycobacterial microwave irradiation 

Notes

The authors are grateful to the Head of Department of Chemistry, Osmania University, Hyderabad and IICT, Hyderabad for providing analytical and biological facilities. D. Ashok is also thankful to DST, PURSE-II programme, Osmania University for the financial assistance. Ananda Rao thanks CSIR, New Delhi, India for the research associate fellowship.

The authors are thankful to Chemveda Life Sciences Pvt. Ltd., IDA, Uppal, and Hyderabad for providing laboratory facilities.

Supplementary material

10593_2018_2323_MOESM1_ESM.pdf (2.1 mb)
ESM 1 (PDF 2100 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • N. H. Kumar Baba
    • 1
    • 2
  • Dongamanti Ashok
    • 3
  • Boddu Ananda Rao
    • 3
  • Madderla Sarasija
    • 4
  • Nandula Y. S. Murthy
    • 5
  1. 1.Department of ChemistryJawaharlal Nehru Technological UniversityHyderabadIndia
  2. 2.Chemveda Life Sciences India Pvt. Ltd., I.D.A. UppalHyderabadIndia
  3. 3.Green and Medicinal Chemistry Laboratory, Department of ChemistryOsmania UniversityHyderabadIndia
  4. 4.Department of ChemistrySatavahana UniversityKarimnagarIndia
  5. 5.Department of Chemistry, Anurag Group of InstitutionsHyderabadIndia

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