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Chemistry of Heterocyclic Compounds

, Volume 54, Issue 6, pp 638–642 | Cite as

An improved synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine

  • Yu-Liu Zhang
  • Cheng-Tao Xu
  • Ting Liu
  • Yong Zhu
  • Yu Luo
Article
  • 36 Downloads

An improved seven-step synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine from dimethyl malonate with 31% overall yield is described. The procedure is operationally simple and practical for the synthesis of the 4-chloro-7H-pyrrolo[2,3-d]pyrimidine building block.

Keywords

pyrimidine Janus kinase inhibitor ozonolysis synthesis 

Notes

This research was financially supported by The National Key Technology R&D Program (No. 2015BAK45B00). We also thank the Laboratory of Organic Functional Molecules, the Sino-French Institute of ECNU for support.

Supplementary material

10593_2018_2320_MOESM1_ESM.pdf (1.9 mb)
ESM 1 (PDF 1918 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Yu-Liu Zhang
    • 1
  • Cheng-Tao Xu
    • 1
  • Ting Liu
    • 1
  • Yong Zhu
    • 2
  • Yu Luo
    • 1
  1. 1.Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghaiP. R. China
  2. 2.Suzhou Highfine Biotech Co., Ltd.SuzhouP. R. China

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