Chemistry of Heterocyclic Compounds

, Volume 54, Issue 2, pp 177–182 | Cite as

Sodium hydrogen sulfate as a catalyst for the synthesis of N,4-diaryl-6-methyl-1-methyl(phenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides via the Biginelli reaction

  • Vladimir L. Gein
  • Tatiana M. Zamaraeva
  • Maksim V. Dmitriev
Article
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N,4-Diaryl-6-methyl-1-methyl(phenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides were synthesized in three-component reaction of N-aryl-3-oxobutanamides, aromatic aldehyde, and N-methylthiourea (N-phenylthiourea) in ethanol in the presence of nontoxic, cheap sodium hydrogen sulfate as a catalyst. Products were obtained in moderate to high yields.

Keywords

aromatic aldehyde keto amide N-methylthiourea N-phenylthiourea 2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide Biginelli reaction 

Supplementary material

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Vladimir L. Gein
    • 1
  • Tatiana M. Zamaraeva
    • 1
  • Maksim V. Dmitriev
    • 2
  1. 1.Perm State Pharmaceutical AcademyPermRussia
  2. 2.Perm State UniversityPermRussia

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