Clinical & Experimental Metastasis

, Volume 36, Issue 6, pp 499–509 | Cite as

Ureteral involvement by metastatic malignant disease

  • Jieping HuEmail author
  • Jun Deng
  • Ju Guo
  • Bin FuEmail author
Research Paper


Ureteral metastases from other primary cancers are very rare. Treatment of these metastases is difficult and outcomes are poor. A thorough literature review was done with the aim of finding characteristics that may influence survival rates of patients with ureteral metastases. Systematic literature searches of PubMed and Web of Science were performed in Jan 2019. A total of 79 papers that included 265 patients with cancer metastases to their ureters were finally considered for evidence synthesis. Prostate, bladder, breast, gut cancer and lymphoma were the predominant primary tumors. The median interval time from primary tumor diagnosis to ureter metastasis was 28.5 months. The median survival time after diagnosis of ureter metastasis was 18 months. Risk factors of survival were analyzed. Age, sex, hydronephrosis, ureter side, and segment were not associated with survival. Interval time and treatment were associated with overall survival. Further analysis indicated that patients who underwent surgery had better outcomes.


Ureter metastases Malignant Hydronephrosis Surgery Survival 


Author contributions

HJP and FB designed the study, HJP and DJ performed the research, HJP and FB analyzed data, and HJP and GJ wrote the paper. HJP accepts full responsibility for the work and/or the conduct of the study, had access to the data, and oversaw the decision to publish.


This study was funded by the Project of the Education Department of Jiangxi Province (GJJ160036, GJJ180007 and GJJ180031).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

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Supplementary material 1 (JPEG 1364 kb)
10585_2019_9989_MOESM2_ESM.xlsx (22 kb)
Supplementary material 2 (XLSX 22 kb)


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of UrologyThe First Affiliated Hospital of Nanchang UniversityNanchangChina

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