Advertisement

Clinical & Experimental Metastasis

, Volume 36, Issue 6, pp 499–509 | Cite as

Ureteral involvement by metastatic malignant disease

  • Jieping HuEmail author
  • Jun Deng
  • Ju Guo
  • Bin FuEmail author
Research Paper

Abstract

Ureteral metastases from other primary cancers are very rare. Treatment of these metastases is difficult and outcomes are poor. A thorough literature review was done with the aim of finding characteristics that may influence survival rates of patients with ureteral metastases. Systematic literature searches of PubMed and Web of Science were performed in Jan 2019. A total of 79 papers that included 265 patients with cancer metastases to their ureters were finally considered for evidence synthesis. Prostate, bladder, breast, gut cancer and lymphoma were the predominant primary tumors. The median interval time from primary tumor diagnosis to ureter metastasis was 28.5 months. The median survival time after diagnosis of ureter metastasis was 18 months. Risk factors of survival were analyzed. Age, sex, hydronephrosis, ureter side, and segment were not associated with survival. Interval time and treatment were associated with overall survival. Further analysis indicated that patients who underwent surgery had better outcomes.

Keywords

Ureter metastases Malignant Hydronephrosis Surgery Survival 

Notes

Author contributions

HJP and FB designed the study, HJP and DJ performed the research, HJP and FB analyzed data, and HJP and GJ wrote the paper. HJP accepts full responsibility for the work and/or the conduct of the study, had access to the data, and oversaw the decision to publish.

Funding

This study was funded by the Project of the Education Department of Jiangxi Province (GJJ160036, GJJ180007 and GJJ180031).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

10585_2019_9989_MOESM1_ESM.jpg (1.3 mb)
Supplementary material 1 (JPEG 1364 kb)
10585_2019_9989_MOESM2_ESM.xlsx (22 kb)
Supplementary material 2 (XLSX 22 kb)

References

  1. 1.
    Siegel RL, Miller KD, Jemal A (2018) Cancer statistics, 2018. CA Cancer J Clin 68(1):7–30Google Scholar
  2. 2.
    Leow JJ, Martin-Doyle W, Fay AP, Choueiri TK, Chang SL, Bellmunt J (2014) A systematic review and meta-analysis of adjuvant and neoadjuvant chemotherapy for upper tract urothelial carcinoma. Eur Urol 66(3):529–541PubMedGoogle Scholar
  3. 3.
    Roupret M, Babjuk M, Comperat E et al (2018) European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2017 update. Eur Urol 73(1):111–122PubMedGoogle Scholar
  4. 4.
    Stow BIX (1909) Fibrolymphosarcomata of both ureters metastatic to a primary lymphosarcomata of the anterior mediastinum of thymus origin. Ann Surg 50(5):901–906PubMedPubMedCentralGoogle Scholar
  5. 5.
    Babaian RJ, Johnson DE, Ayala AG, Sie ET (1979) Secondary tumors of ureter. Urology 14(4):341–343PubMedGoogle Scholar
  6. 6.
    Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151(4):264–269, W264PubMedGoogle Scholar
  7. 7.
    Chung HS, Kim MS, Cho YH et al (2017) A rare presentation of metastatic prostate cancer, initially a suspect for urothelial cell carcinoma of the ureter: a case report. BMC Urol 17(1):37PubMedPubMedCentralGoogle Scholar
  8. 8.
    Carson WJ (1925) Metastatic carcinoma in the ureter: associated with ureteral stricture. Ann Surg 82(1):142–152PubMedPubMedCentralGoogle Scholar
  9. 9.
    Carson WJ (1927) Metastatic carcinoma in the ureter: report of additional cases. Ann Surg 86(4):549–555PubMedPubMedCentralGoogle Scholar
  10. 10.
    Mackenzie DW, Ratner M (1931) Metastatic growths in the ureter: a report of three cases and a brief review of the literature. Can Med Assoc J 25(3):265–270PubMedPubMedCentralGoogle Scholar
  11. 11.
    Kost LV, Leberman PR (1965) Metastatic carcinoma to the ureter: a case report. J Urol 93:367–369PubMedGoogle Scholar
  12. 12.
    Khan AU, Utz DC (1975) Clinical management of carcinoma of prostate, associated with bilateral ureteral obstruction. J Urol 113(6):816–819PubMedGoogle Scholar
  13. 13.
    Zollinger RW 2nd, Wise HA 2nd, Clausen KP (1981) An unusual presentation of intrinsic ureteral obstruction secondary to carcinoma of the prostate: a case report. J Urol 125(1):132–133PubMedGoogle Scholar
  14. 14.
    Benejam R, Carroll TJ, Loening S (1987) Prostate carcinoma metastatic to ureter. Urology 29(3):325–327PubMedGoogle Scholar
  15. 15.
    Hulse CA, O’Neill TK (1989) Adenocarcinoma of the prostate metastatic to the ureter with an associated ureteral stone. J Urol 142(5):1312–1313PubMedGoogle Scholar
  16. 16.
    Chalasani V, Macek P, O’Neill GF, Barret W (2010) Ureteric stricture secondary to unusual extension of prostatic adenocarcinoma. Can J Urol 17(1):5031–5034PubMedGoogle Scholar
  17. 17.
    Jallad S, Turo R, Kimuli M, Smith J, Jain S (2012) Ureteric stricture: an unusual presentation of metastatic prostate adenocarcinoma. Ann R Coll Surg Engl 94(7):e213–e214PubMedPubMedCentralGoogle Scholar
  18. 18.
    Schneider S, Popp D, Denzinger S, Otto W (2012) A rare location of metastasis from prostate cancer: hydronephrosis associated with ureteral metastasis. Adv Urol 2012:656023PubMedGoogle Scholar
  19. 19.
    Hongo H, Kosaka T, Yoshimine S, Oya M (2014) Ureteral metastasis from prostate cancer. BMJ Case Rep 2014:bcr2014206736PubMedPubMedCentralGoogle Scholar
  20. 20.
    Zhang T, Wang Q, Min J et al (2014) Metastasis to the proximal ureter from prostatic adenocarcinoma: a rare metastatic pattern. Cuaj-Can Urol Assoc 8(11–12):E859–E861Google Scholar
  21. 21.
    Schallier D, Rappe B, Carprieaux M, Vandenbroucke F (2015) Ureteral metastasis: uncommon manifestation in prostate cancer. Anticancer Res 35(11):6317–6320PubMedGoogle Scholar
  22. 22.
    Osman Y, El-Tabey N, Abdel-Latif M, Mosbah A, Moustafa N, Shaaban A (2007) The value of frozen-section analysis of ureteric margins on surgical decision-making in patients undergoing radical cystectomy for bladder cancer. BJU Int 99(1):81–84PubMedGoogle Scholar
  23. 23.
    Klee LW, Adams MC, Foster RS (1990) Ureteral stump transitional cell carcinoma in a patient with recurrent superficial bladder cancer: an argument for complete nephroureterectomy in selected patients. J Urol 144(4):972–973PubMedGoogle Scholar
  24. 24.
    Oldbring J, Glifberg I, Mikulowski P, Hellsten S (1989) Carcinoma of the renal pelvis and ureter following bladder carcinoma: frequency, risk factors and clinicopathological findings. J Urol 141(6):1311–1313PubMedGoogle Scholar
  25. 25.
    Sherwood T (1971) Upper urinary tract tumours following on bladder carcinoma: natural history of urothelial neoplastic disease. Br J Radiol 44(518):137–141PubMedGoogle Scholar
  26. 26.
    Sathianathen NJ, Butaney M, Weight CJ, Kumar R, Konety BR (2018) Urinary biomarkers in the evaluation of primary hematuria: a systematic review and meta-analysis. Bladder Cancer 4(4):353–363PubMedPubMedCentralGoogle Scholar
  27. 27.
    March-Villalba JA, Panach-Navarrete J, Herrero-Cervera MJ, Alino-Pellicer S, Martinez-Jabaloyas JM (2018) hTERT mRNA expression in urine as a useful diagnostic tool in bladder cancer. Comparison with cytology and NMP22 BladderCheck Test(R). Actas Urol Esp 42(8):524–530PubMedGoogle Scholar
  28. 28.
    Dong F, Shen Y, Xu T et al (2018) Effectiveness of urine fibronectin as a non-invasive diagnostic biomarker in bladder cancer patients: a systematic review and meta-analysis. World J Surg Oncol 16(1):61PubMedPubMedCentralGoogle Scholar
  29. 29.
    Caskey CI, Scatarige JC, Fishman EK (1991) Distribution of metastases in breast carcinoma: CT evaluation of the abdomen. Clin Imaging 15(3):166–171PubMedGoogle Scholar
  30. 30.
    Feun LG, Drelichman A, Singhakowinta A, Vaitkevicius VK (1979) Ureteral obstruction secondary to metastatic breast carcinoma. Cancer 44(3):1164–1171PubMedGoogle Scholar
  31. 31.
    Grabstald H, Sherman RS (1969) Radiographic diagnosis of ureteral involvement by metastatic breast cancer. Radiology 92(6):1184–1187PubMedGoogle Scholar
  32. 32.
    Hudolin T, Nola N, Milas I, Nola M, Juretic A (2004) Ureteral metastasis of occult breast cancer. Breast 13(6):530–532PubMedGoogle Scholar
  33. 33.
    Mondaini N, Giubilei G, Nesi G, Bongini A, Girardi LR, Ponchietti R (2005) Carcinoma of the breast metastatic to the ureter seven years later. Int J Urol 12(8):763–764PubMedGoogle Scholar
  34. 34.
    Xiao W, Zheng S, Yang A et al (2018) Breast cancer subtypes and the risk of distant metastasis at initial diagnosis: a population-based study. Cancer Manag Res 10:5329–5338PubMedPubMedCentralGoogle Scholar
  35. 35.
    Presman D, Ehrlich L (1948) Metastatic tumors of the ureter. J Urol 59(3):312–325PubMedGoogle Scholar
  36. 36.
    Fitch WP, Robinson JR, Radwin HW (1976) Metastatic carcinoma of the ureter. Arch Surg 111(8):874–876PubMedGoogle Scholar
  37. 37.
    Heesakkers JP, Delaere KP, Nap M (1999) Metastasis of gastric carcinoma to the ureter. Urology 54(3):561PubMedGoogle Scholar
  38. 38.
    Yeh HC, Hsiao HL, Chang TH, Wang SL, Huang CH, Wu WJ (2008) Postoperative disseminated intravascular coagulation in a patient with ureteral metastasis from gastric cancer. Kaohsiung J Med Sci 24(6):319–323PubMedGoogle Scholar
  39. 39.
    Vilaseca AC, Musquera MF, Ribal MJC, Alcaraz AA (2013) Metastasis of gastric carcinoma simulating a urothelial tumor. Case report and review of the literature. Arch Esp Urol 66(9):885–889Google Scholar
  40. 40.
    Thompson HR (1957) Carcinoma of pelvic colon; secondary deposit in left ureter simulating a primary tumour; left hydronephrosis. Proc R Soc Med 50(4):269–270PubMedGoogle Scholar
  41. 41.
    Stearns DB, Gordon SK (1960) Ureteral metastasis secondary to carcinoma of the large bowel. Am J Surg 99:244–246PubMedGoogle Scholar
  42. 42.
    Williams DF, Chaffey BT (1966) Metastatic adenocarcinoma of the sigmoid colon masquerading as bilateral intraluminal ureteral papillomas. Br J Urol 38(5):563–566PubMedGoogle Scholar
  43. 43.
    Thorup B, Fabrin K, Lund L (2001) Implantation metastasis in ureter from a colonic adenocarcinoma. Scand J Urol Nephrol 35(5):420–421PubMedGoogle Scholar
  44. 44.
    Ueda K, Nagayama H, Narita K et al (2001) Extended surgery with en bloc resection of the right common iliac vessels for lymph node metastasis of mucinous colon carcinoma: report of a case. Surg Today 31(3):238–241PubMedGoogle Scholar
  45. 45.
    Stief CG, Jonas U, Raab R (2002) Long-term follow-up after surgery for advanced colorectal carcinoma involving the urogenital tract. Eur Urol 41(5):546–550PubMedGoogle Scholar
  46. 46.
    Schmulewitz N, Hawes R (2004) Ureteral metastasis from an appendiceal carcinoma and diagnosis by endoscopic ultrasound-guided fine-needle aspiration. Endoscopy 36(5):447–449PubMedGoogle Scholar
  47. 47.
    Katsuno G, Kagawa S, Kokudo Y et al (2005) Ureteral metastasis from appendiceal cancer: report of a case. Surg Today 35(2):168–171PubMedGoogle Scholar
  48. 48.
    Kaku S, Tanaka T, Ohtuka T et al (2006) Perisacral gastrointestinal stromal tumor with intracranial metastasis—Case report. Neurol Med-Chir 46(5):254–257Google Scholar
  49. 49.
    Romano G, Bianco F, Delrio P et al (2010) From mininvasive to maxinvasive surgery in colorectal cancer: modem evolution of oncologic specialized units. Acta Chir Iugosl 57(3):73–75PubMedGoogle Scholar
  50. 50.
    Darrad M, Harper S, Verghese A, Leveckis J, Pathak S (2012) Synchronous and metachronous ureteric metastases from adenocarcinoma of the colon. Int J Clin Oncol 17(2):185–188PubMedGoogle Scholar
  51. 51.
    Nikolaos F, Panagiotis A, Konstantinos B, Vassilios S, Iraklis P (2014) Distant ureteral metastasis from colon adenocarcinoma: report of a case and review of the literature. Case Rep Urol 2014:196425PubMedPubMedCentralGoogle Scholar
  52. 52.
    Chan S, Oliver KA, Gray NA (2016) An association between membranoproliferative glomerulonephritis and metastatic colorectal carcinoma: a case report. J Med Case Rep 10:199PubMedPubMedCentralGoogle Scholar
  53. 53.
    Chiu KY, Ho HC, Chen JT et al (2001) Renal cell carcinoma metastasized to the ureteral stump. Zhonghua Yi Xue Za Zhi (Taipei) 64(1):64–68Google Scholar
  54. 54.
    Takei H, Barrios R, Monzon FA (2013) Cytogenomics and gene expression in a case of metachronous bilateral renal cell carcinomas with drop metastasis: resolving a diagnostic dilemma with molecular technologies. Pathol Int 63(6):326–332PubMedGoogle Scholar
  55. 55.
    Lee G, Sharma SD, Bullock KN (1998) An unusual case of renal cell carcinoma with two rare metastases. Scand J Urol Nephrol 32(3):239–240PubMedGoogle Scholar
  56. 56.
    Yang GE, Seo JW, Park JH (2012) Distal ureteral seeding metastasis of collecting duct carcinoma manifesting as deep vein thrombosis. Clin Radiol 67(9):936–939PubMedGoogle Scholar
  57. 57.
    Diner EK, Williams CR, Behari A, Pinto PA, Linehan WM, Walther MM (2005) Metastatic renal cell carcinoma to contralateral ureter presenting as acute obstructive renal failure after radical nephrectomy. Urology 65(5):1001PubMedGoogle Scholar
  58. 58.
    Zeh N, Wild PJ, Bode PK et al (2013) Retroperitoneal teratoma with somatic malignant transformation: a papillary renal cell carcinoma in a testicular germ cell tumour metastasis following platinum-based chemotherapy. BMC Urol 13:9PubMedPubMedCentralGoogle Scholar
  59. 59.
    Esrig D, Kanellos AW, Freeman JA, Stein JP, Kiyabu M, Ahlering TE (1994) Metastatic renal cell carcinoma to the contralateral ureter. Urology 44(2):278–281PubMedGoogle Scholar
  60. 60.
    Zorn KC, Orvieto MA, Mikhail AA et al (2006) Solitary ureteral metastases of renal cell carcinoma. Urology 68(2):428-e5Google Scholar
  61. 61.
    Shrivastava S, Barmon D, Deka P, Ch Kataki A, Choudhary BK (2014) Sarcomatoid carcinoma of the cervix with foci of malignant melanoma. J Midlife Health 5(1):41–44PubMedPubMedCentralGoogle Scholar
  62. 62.
    DiPietro M, Zeman RK, Keohane M, Rosenfield AT (1983) Oat cell carcinoma metastatic to ureter. Urology 22(4):419–420PubMedGoogle Scholar
  63. 63.
    Stenner J, Arista-Nasr J, Lenero-Llaca E, Keirns C, Gabilondo-Navarro F (1996) Adenocarcinoma of the ampulla of Vater and head of the pancreas metastatic to the ureter: report of 2 cases. J Urol 156(5):1765PubMedGoogle Scholar
  64. 64.
    Comiter S, Glasser J, Al-Askari S (1992) Ureteral obstruction in a patient with Burkitt’s lymphoma and AIDS. Urology 39(3):277–280PubMedGoogle Scholar
  65. 65.
    Tozzini A, Bulleri A, Orsitto E, Morelli G, Pieri L (1999) Hodgkin’s lymphoma: an isolated case of involvement of the ureter. Eur Radiol 9(2):344–346PubMedGoogle Scholar
  66. 66.
    Buck DS, Peterson MS, Borochovitz D, Bloom EJ (1992) Non-Hodgkin lymphoma of the ureter: CT demonstration with pathologic correlation. Urol Radiol 14(3):183–187PubMedGoogle Scholar
  67. 67.
    Caro DJ (1985) Clinical presentation of metastatic lymphoma to ureter. Urology 26(1):53–55PubMedGoogle Scholar
  68. 68.
    Goswami AP (1977) Metastatic cancer to the ureter and kidney from malignant lymphoma. A review of the literature. J Urol 117(3):381–382PubMedGoogle Scholar
  69. 69.
    Gakis G, Merseburger AS, Sotlar K, Kuczyk MA, Sievert KD, Stenzl A (2009) Metastasis of malignant melanoma in the ureter: possible algorithms for a therapeutic approach. Int J Urol 16(4):407–409PubMedGoogle Scholar
  70. 70.
    Samellas W, Marks AR (1961) Metastatic melanoma of the urinary tract. J Urol 85:21–23PubMedGoogle Scholar
  71. 71.
    Judd RL (1962) Melanoma of the ureter: a case report. J Urol 87:805–807PubMedGoogle Scholar
  72. 72.
    Strohmeyer T, Buszello H (1992) Late metastases in seminoma: incidence, localization, and therapeutic implications. Urology 39(6):515–518PubMedGoogle Scholar
  73. 73.
    Davies RJ, King DM, Hendry WF (1992) Case report: intra-ureteric metastasis from testicular teratoma. Clin Radiol 46(5):354–356PubMedGoogle Scholar
  74. 74.
    Johnson RD, Johnson JR, Bannayan GA (1981) Seminoma metastatic to ureter. Urology 17(3):281–283PubMedGoogle Scholar
  75. 75.
    Rutigliano DN, Georges A, Wolden SL, Kayton ML, Meyers P, La Quaglia MP (2007) Ureteral reconstruction for retroperitoneal tumors in children. J Pediatr Surg 42(2):355–358PubMedGoogle Scholar
  76. 76.
    Winfield HL, De Las Casas LE, Greenfield WW, Santin AD, McKenney JK (2007) Low-grade fibromyxoid sarcoma presenting clinically as a primary ovarian neoplasm: a case report. Int J Gynecol Pathol 26(2):173–176PubMedGoogle Scholar
  77. 77.
    Raj GV, Madden JF, Anderson EE (2003) Liposarcoma presenting as an intraluminal ureteral mass. Urology 61(5):1035PubMedGoogle Scholar
  78. 78.
    Gungor T, Altinkaya SO, Akbay S, Bilge U, Mollamahmutoglu L (2010) Malign mural nodules associated with serous ovarian tumor of borderline malignancy: a case report and literature review. Arch Gynecol Obstet 281(3):485–490PubMedGoogle Scholar
  79. 79.
    Kanso F, Lefevre JH, Mourra N, Sebe P, Tiret E, Parc Y (2010) Massive infiltration of the left kidney and the ureter from rectal cancer developing 51 years after ureterosigmoidostomy. Colorectal Dis 12(10 Online):e343–e344PubMedGoogle Scholar
  80. 80.
    Ebine T, Shindo M, Fujita K, Mikami S (2014) Metastatic ureteral tumor from colon cancer: a case report. Hinyokika Kiyo 60(3):143–146PubMedGoogle Scholar
  81. 81.
    Yamada R, Yamaguchi S, Seguchi T, Sonoda T (1994) Solitary metastasis to residual ureter resulting from renal cell carcinoma after radical nephrectomy: report of a case. Hinyokika Kiyo 40(3):233–236PubMedGoogle Scholar
  82. 82.
    Chen Q, Li L, Wang G, Hu J, Sun T, Fu B (2017) Do histological variants in urothelial carcinoma of the bladder portend poor prognosis? A systematic review and meta-analysis. Oncotarget 8(29):48263–48271PubMedPubMedCentralGoogle Scholar
  83. 83.
    Naser-Tavakolian A, Ghodoussipour S, Djaladat H (2019) Upper urinary tract recurrence following bladder cancer therapy: a review of surveillance and management. Curr Opin Urol 29(3):189–197PubMedGoogle Scholar

Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of UrologyThe First Affiliated Hospital of Nanchang UniversityNanchangChina

Personalised recommendations