Child Psychiatry & Human Development

, Volume 50, Issue 2, pp 268–277 | Cite as

N-methyl-d-aspartate Partial Agonist Enhanced Intensive Cognitive-Behavioral Therapy of Panic Disorder in Adolescents

  • Ovsanna LeyferEmail author
  • Aubrey Carpenter
  • Donna Pincus
Original Article


Panic disorder (PD) can result in significant functional impairment. Studies of cognitive behavioral therapy (CBT) for PD have demonstrated response rates ranging between 38 and 65%. d-cycloserine (DCS), a partial NMDA agonist, may enhance the effects of exposure-based therapy for PD in adults; however, no studies have examined its effect in adolescents with PD. This study examined the feasibility and acceptability of the use of DCS to augment intensive CBT for PD in adolescents. Twenty-four adolescents (ages 12–17) participated in this randomized, double-blinded, placebo-controlled trial, to compare CBT + DCS to CBT + placebo. The results demonstrated the feasibility and acceptability of the treatment to participants. No significant differences were found between the two groups, but both groups showed significant improvement. This is the first investigation of DCS in the treatment of PD in adolescents and it provides initial support for a more extensive study of DCS augmentation of CBT among adolescents with PD.


Anxiety Panic disorder d-Cycloserine Cognitive-behavioral therapy Adolescents Outcome 



This study was funded by the Brain and Behavior Research Foundation Grant No. 19050 to Ovsanna Leyfer, Ph.D.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Psychological and Brain Sciences, Center for Anxiety and Related DisordersBoston UniversityBostonUSA
  2. 2.Massachusetts General HospitalBostonUSA

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