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Cellulose

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Temperature/pH dual sensitive Hericium erinaceus residue carboxymethyl chitin/poly (N-isopropyl acrylamide) sequential IPN hydrogels

  • Jing Liao
  • Huihua HuangEmail author
Original Research
  • 38 Downloads

Abstract

In this study, a novel temperature/pH dual responsive hydrogel, based on Hericium erinaceus residue carboxymethyl chitin (HCMC) and poly (N-isopropylacrylamide) (PNIPAm), was synthesized by sequential IPN technique. Series of IPN hydrogels were obtained by varying initial N-isopropylacrylamide (NIPAm) concentrations. The structure, morphology, thermal property, transparency, mechanical property, swelling kinetics, temperature/pH responses and 5-Fu release behavior of the prepared hydrogels were systematically investigated. The structure analysis results showed that the IPN hydrogels were successfully synthesized. The prepared hydrogels showed more compact network structure and enhanced mechanical property as NIPAm concentration increased, but reduced transparency, swelling degree and 5-Fu release ratio. More importantly, HCMC and PNIPAm ensured the pH and temperature responses, respectively. 5-Fu could be gradually released from the prepared hydrogels, which followed Fickian diffusion model. Therefore, the prepared hydrogels may be served as promising materials for drug delivery systems.

Keywords

Hericium erinaceus residue Carboxymethyl chitin Poly (N-isopropylacrylamide) IPN hydrogel Temperature/pH response 

Notes

Acknowledgments

This work is supported by National Natural Science Foundation of China under Grant Nos. 31471673 and 31271978.

Supplementary material

10570_2019_2837_MOESM1_ESM.docx (374 kb)
Supplementary material 1 (DOCX 374 kb)

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.School of Food Science and EngineeringSouth China University of TechnologyGuangzhouChina

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