Long-term treatment with arsenite activates HER1 and HER2 through upregulating EGF, TGFα, and HSP90 in a human uroepithelial cell line

  • Peiyu Jin
  • Jieyu Liu
  • Qing Zhou
  • Sihao Li
  • Weijue Liu
  • Shuhua XiEmail author
Short Communication

Numerous reports have established a robust dose-response association among arsenic levels in drinking water and incidences of bladder cancer (Aballay et al. 2012; Su et al. 2011). However, the exact molecular mechanisms are not clearly explained until now. Existing evidences have indicated that the human epidermal growth factor receptors (HERs) are linked to the pathogenesis of human cancers (Kriegmair et al. 2018; Sanguedolce et al. 2019; Steuer et al. 2018; Xue et al. 2018) and have a prominent function in the advancement as well as progression of epithelial cancer (Appert-Collin et al. 2015; Esparis-Ogando et al. 2016; Yu et al. 2018). Overexpression of HER1 and HER2 has been also reported in the patients with bladder cancer (Rotterud et al. 2005; Xue et al. 2018).

Nevertheless, there are not any specific studies that focus on the mechanisms of HER1 and HER2 activation during arsenic-induced urothelial hyperplasia. Increased proliferation and migration have long been regarded as an...


Arsenite Cell proliferation Urothelium Human Epidermal Growth Factor Receptor 


Funding information

This work was supported by the National Natural Science Foundation of China (NSFC) (81673207 and 81373023) and the Program for Liaoning Innovative Research Team in University (LNIRT) (201610159000037).

Compliance with ethical standards

Conflict of interests

The authors declare that they have no conflict of interest.

Supplementary material

10565_2019_9500_MOESM1_ESM.docx (10.2 mb)
ESM 1 (DOCX 10452 kb).


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of Occupational and Environmental Health, School of Public HealthChina Medical UniversityShenyangPeople’s Republic of China

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