Cell Biology and Toxicology

, Volume 35, Issue 6, pp 493–502 | Cite as

Mitochondrial dysfunction and chronic lung disease

  • Tingting Fang
  • Manni Wang
  • Hengyi XiaoEmail author
  • Xiawei WeiEmail author


The functions of body gradually decrease as the age increases, leading to a higher frequency of incidence of age-related diseases. Diseases associated with aging in the respiratory system include chronic obstructive pulmonary disease (COPD), IPF (idiopathic pulmonary fibrosis), asthma, lung cancer, and so on. The mitochondrial dysfunction is not only a sign of aging, but also is a disease trigger. This article aims to explain mitochondrial dysfunction as an aging marker, and its role in aging diseases of lung. We also discuss whether the mitochondria can be used as a target for the treatment of aging lung disease.


Mitochondrial dysfunction Chronic lung diseases mtROS mtDNA Mitochondrial dynamic 



TT-F, MN-W, XW-W, and HY-X are supported by Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital.TT-F and MN-W are co-first authors.


This work is supported by the National Key Research and Development Program of China (No. 2016YFA0201402) and the National Natural Science Foundation of China (No. 81602492).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China HospitalSichuan University and National Collaborative Innovation CenterChengduChina

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