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Predictive value of electrocardiography-gated myocardial perfusion imaging to new-onset heart failure in patients with chronic kidney disease: findings from the J-ACCESS 3 study

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Abstract

The incidence of heart failure (HF) increases in patients with chronic kidney disease (CKD). Factors that could predict patients with CKD who are at high risk for developing HF should be identified. We analysed clinical parameters and stress/rest myocardial perfusion imaging (MPI) findings derived from 499 patients with CKD by the Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT 3 (J-ACCESS 3) to clarify predictors of new-onset HF. Forty-one patients with congestive HF in the J-ACCESS 3 database were followed up for three years. Multivariable Cox hazards models selected haemoglobin (hazard ratio [HR] 0.809; 95% confidence interval [CI] 0.679–0.964), summed stress score (HR 1.082; 95% CI 1.016–1.151) and left ventricular ejection fraction (HR 0.970; 95% CI 0.949–0.992) as independent predictors of new-onset HF. Haemoglobin combined with summed stress scores and ejection fraction had the greatest incremental prognostic value over any one or more combined factors (global χ2, 29.9). Anaemia, stress-induced myocardial ischaemia, and left ventricular contraction are independent predictors of risk of new-onset HF in patients with CKD. Stress/rest MPI provides additional information with which to identify patients with CKD at greater risk of new-onset HF.

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Abbreviations

CAD:

Coronary artery disease

CKD:

Chronic kidney disease

EF:

Ejection fraction

eGFR:

Estimated glomerular filtration rate

HF:

Heart failure

MI:

Myocardial infarction

MPI:

Myocardial perfusion imaging

SPECT:

Single photon emission computerized tomography

SSS:

Summed stress score

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Acknowledgements

The authors are grateful to the physicians and technologists who participated in this study and are listed elsewhere. We also thank the J-ACCESS office staff for implementing the study.

Funding

This study was supported by grants from the Japan Cardiovascular Research Foundation.

Author information

Correspondence to Tsunehiko Nishimura.

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Conflict of interest:

All authors declare that they have no conflict of interests.

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None to declare.

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Nanasato, M., Matsuo, S., Nakajima, K. et al. Predictive value of electrocardiography-gated myocardial perfusion imaging to new-onset heart failure in patients with chronic kidney disease: findings from the J-ACCESS 3 study. Int J Cardiovasc Imaging (2020). https://doi.org/10.1007/s10554-019-01761-z

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Keywords

  • Cardio-renal syndrome
  • Anaemia
  • Stress-induced myocardial ischemia