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The International Journal of Cardiovascular Imaging

, Volume 35, Issue 11, pp 2095–2102 | Cite as

Cardiac magnetic resonance-tissue tracking for the early prediction of adverse left ventricular remodeling after ST-segment elevation myocardial infarction

  • Min Jae Cha
  • Jeong Hyun Lee
  • Hye Na Jung
  • Yiseul Kim
  • Yeon Hyeon Choe
  • Sung Mok KimEmail author
Original Paper
  • 77 Downloads

Abstract

Cardiac magnetic resonance-tissue tracking (CMR-TT)-derived myocardial strain after ST-elevation myocardial infarction (STEMI) is related to adverse cardiac events. We aimed to investigate the feasibility of CMR-TT for the early prediction of adverse left ventricular (LV) remodeling after STEMI. We retrospectively searched our institution’s STEMI registry for patients who underwent reperfusion therapy, post-reperfusion CMR within 1 week after STEMI, and follow-up CMR. CMR-TT analysis was performed using cine imaging of post-reperfusion CMR. Adverse LV remodeling was defined as an increase in end-diastolic LV volume by 20% or more on follow-up CMR (median interval between serial CMR exams, 197 days; interquartile, 174–241 days). A total of 82 patients (age, 59.2 ± 11.1 years; male:female = 73:9) were included and divided into two groups: STEMI without (n = 62) and with (n = 20) adverse LV remodeling. Patients with LV remodeling showed significantly higher peak creatine kinase-MB and troponin I levels and a larger infarct size compared with those without LV remodeling (p = 0.001, p = 0.001, and p = 0.010, respectively). Global circumferential, radial, and longitudinal strain (GLS) also differed significantly between the groups (p = 0.001, p = 0.004, and p < 0.001, respectively). Logistic regression and receiver operating characteristic curve analyses demonstrated that GLS was an independent predictor of LV remodeling [odds ratio (OR) = 1.282, 95% confidence interval (CI) = 1.060–1.55 p = 0.011] with an optimal cut-off of − 12.84 (AUC = 0.756, 95% CI = 0.636–0.887, p < 0.001). CMR-TT-derived GLS may aid the early prediction of adverse LV remodeling after reperfusion, within 1 week after STEMI.

Keywords

Cardiac magnetic resonance imaging Ventricular remodeling ST-segment elevation myocardial infarction 

Notes

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Informed consent

The institutional review board of our institution approved the study, and informed consent was waived.

Research involving human and animal participants

The ethical standards of the responsible committee on human experimentation (institutional and national) and Declaration of Helsinki of 1964 (revised in 2008) were followed.

Supplementary material

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of RadiologyChung-Ang University Hospital, Chung-Ang University College of MedicineSeoulSouth Korea
  2. 2.Department of RadiologySamsung Medical Center, Sungkyunkwan University School of MedicineSeoulSouth Korea
  3. 3.Cardiovascular Imaging CenterSamsung Medical Center, Sungkyunkwan University School of MedicineSeoulSouth Korea

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