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The International Journal of Cardiovascular Imaging

, Volume 35, Issue 9, pp 1619–1626 | Cite as

Evaluation of left atrial volume and function by real time three-dimensional echocardiography in anemic patients without overt heart disease before and after anemia correction

  • Seçkin DereliEmail author
  • Adil Bayramoğlu
  • Nurtaç Özer
  • Sinan Cerşit
  • Ahmet Kaya
  • Muhammet Özbilen
Original Paper

Abstract

There are few data on the effects of low hemoglobine levels on the left atrium (LA) in anemic patients. Our aim was to evaluate left atrial (LA) volume and functions in anemic patients using real time three-dimensional echocardiography (RT3DE) and also to investigate changes in variables of LA after the correction of anemia. In total, 55 iron-deficiency anemia patients without traditional cardiovascular (CV) risk factors and 30 age- and gender-matched controls were studied. Assessments included history, physical examination and echocardiography. Of the 55 patients with anemia enrolled, 50 (39 females and 11 males 40.3 years) were followed and underwent echocardiography after correction of the anemia. LA maximum volume (LAVmax), LA minimal volume (LAVmin), LAVmax index (LAVI), before atrial contraction volume (LAVpreA), LA total emptying fraction, LA active emptying volume were higher in anemic patients. LA passive emptying fraction was significantly lower in anemic patients. Following correction of anemia, LA volume and function parameters were observed to be significantly reduced. Moreover, significant increase was noted in LA passive emptying fraction. Correlation analysis was performed and a significant negative correlation was noted between the percentage change in hemoglobin level and percentage change in LAVI (r = − 0.382, p = 0.003). It was shown that volume and functions of LA are impaired in anemic patients. However impaired parameters were improved after correction of anemia. It may be thought that RT3DE LA parameters can be used as an important preclinical marker of disease pathogenesis before developing heart failure or atrial arrhythmia.

Keywords

Left atrium Left atrial volume and function Three dimensional transthoracic echocardiography Diastolic dysfunction 

Notes

Funding

None were declared.

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of CardiologyOrdu State HospitalOrduTurkey
  2. 2.Faculty of Medicine, Department of CardiologyOrdu UniversityOrduTurkey
  3. 3.Department of CardiologyKoşuyolu Kartal Heart Training and Research HospitalİstanbulTurkey
  4. 4.Faculty of Medicine, Department of Internal MedicineOrdu UniversityOrduTurkey

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